MELANOCYTE-STIMULATING HORMONE + ADRENOCORTICOTROPHIC HORMONE - THEIR RELATION TO PIGMENTATION
MELANOCYTE-STIMULATING HORMONE + ADRENOCORTICOTROPHIC HORMONE - THEIR RELATION TO PIGMENTATION
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DOI：
10.1056/nejm196403122701101
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发表时间：
1964-01-01
影响因子：
158.5
通讯作者：
MCGUIRE, JS
中科院分区：
文献类型：
--
作者：
LERNER, AB;MCGUIRE, JS
将均质猪ACTH和α MSH分别大量给予双侧肾上腺切除的人类受试者。每日肌内维持剂量为24 mg ACTH和8 mg α MSH。在施用每种肽后，皮肤强烈变暗。虽然适量的α-MSH和ACTH可以诱导人类皮肤变黑，但尚不清楚哪种肽对患有内分泌疾病的给定患者中发生的色素沉着过度贡献更大。
Homogeneous pig ACTH and alpha MSH were given separately in large quantities to a bilaterally adrenalectomized human subject. The daily intramuscular maintenance dose was 24 mg of ACTH and 8 mg of alpha MSH. Intense darkening of the skin followed administration of each peptide. Although alpha MSH and ACTH in appropriate amounts can induce darkening of human skin, it is not known which peptide contributes more to the hyperpigmentation that occurs in a given patient with endocrine disease.