Sexual mixing patterns in the spread of gonococcal and chlamydial infections
Sexual mixing patterns in the spread of gonococcal and chlamydial infections
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DOI：
10.2105/ajph.89.6.825
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发表时间：
1999-06-01
影响因子：
12.7
通讯作者：
Holmes, KK
中科院分区：
文献类型：
--
作者：
Aral, SO;Hughes, JP;Holmes, KK
目标.本研究试图在性传播疾病（STD）门诊就诊者中定义（1）性伴侣选择模式，（2）与每种混合模式相关的淋球菌或衣原体感染的相对风险，以及（3）选定的链接和潜在的和实际的桥梁人群。根据研究参与者及其伴侣的特征计算混合矩阵。确定了研究参与者与不同类型伴侣的感染风险，并使用比值比来估计不一致与一致伴侣的相对感染风险。在种族/民族、年龄、教育程度和伴侣数量方面不一致的伴侣关系与淋病和衣原体感染的显著风险相关。在低患病率亚群中，亚群内混合与衣原体感染相关，与高患病率亚群的直接联系与淋病相关。混合模式影响特定感染的风险，应将其纳入个人风险评估以及人群筛查、健康教育和伴侣通知策略的设计中。
Objectives. This study sought to define, among sexually transmitted disease (STD) clinic attendees, (1) patterns of sex partner selection, (2) relative risks for gonococcal or chlamydial infection associated with each mixing pattern, and (3) selected links and potential and actual bridge populations.Methods. Mixing matrices were computed based on characteristics of the study participants and their partners. Risk of infection was determined in study participants with various types of partners, and odds ratios were used to estimate relative risk of infection for discordant vs concordant partnerships.Results. Partnerships discordant in terms of race/ethnicity, age, education, and number of partners were associated with significant risk for gonorrhea and chlamydial infection. In low-prevalence subpopulations, within-subpopulation mixing was associated with chlamydial infection, and direct links with high-prevalence subpopulations were associated with gonorrhea.Conclusions. Mixing patterns influence the risk of specific infections, and they should be included in risk assessments for individuals and in the design of screening, health education, and partner notification strategies for populations.