HEROIN REWARD IS DEPENDENT ON A DOPAMINERGIC SUBSTRATE
HEROIN REWARD IS DEPENDENT ON A DOPAMINERGIC SUBSTRATE
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DOI：
10.1016/0024-3205(81)90519-1
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发表时间：
1981-01-01
期刊：
影响因子：
6.1
通讯作者：
WISE, RA
中科院分区：
文献类型：
--
作者：
BOZARTH, MA;WISE, RA
海洛因的奖励属性被阻断预处理与纳洛酮或匹莫齐特，表明这种阿片受体介导的作用是依赖于多巴胺能底物。多巴胺能机制参与了这种效应，这支持了阿片类药物和其他奖赏来源激活类似神经底物的观点。
The rewarding property of heroin was blocked by pretreatment with either naloxone or pimozide, suggesting that this opiate-receptor mediated effect is dependent on a dopaminergic substrate. The involvement of a dopaminergic mechanism in this effect supports the notion that opiates and other sources of reward activate a similar neural substrate.