Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: a prospective single blind randomized trial
Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: a prospective single blind randomized trial
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DOI：
10.1007/s10482-015-0448-9
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发表时间：
2015-06-01
影响因子：
2.6
通讯作者：
Xu, Jin-Ke
中科院分区：
文献类型：
--
作者：
Mi, Guo-Lin;Zhao, Lei;Xu, Jin-Ke
婴儿绞痛，不明原因的过度哭泣，是家庭的主要负担，影响约10 - 30%的婴儿。尽管几十年的研究，婴儿绞痛的确切原因和治疗仍然难以捉摸。罗伊氏乳杆菌（DSM 17938）在婴儿肠绞痛中的使用有些争议，因此，我们设计了这项研究，以评估其在婴儿肠绞痛中的疗效。我们在一项安慰剂对照的观察性随机研究中招募了主要或完全母乳喂养的婴儿，年龄小于4个月。受试者被分配接受L。剂量为10（8）个菌落形成单位的罗伊氏菌（n = 21）和安慰剂（n = 21）。安慰剂是不含活微生物的相同制剂。对受试者进行21天的治疗，并随访4周。在研究期结束时评估了治疗成功（主要结局）、每天哭泣时间的减少、父母满意度和母亲抑郁症的减少（次要结局）。在益生菌组的所有婴儿（100%）中观察到治疗成功，而在安慰剂组的15. 7%中观察到治疗成功。与安慰剂组（120.6 +/-A20.0 min/天）相比，益生菌组的平均每日哭泣时间从200.9 +/-A6.3 min/天更显著地减少至32.1 +/-A8.3 min/天（P <0.01）。此外，在整个研究期间，益生菌组的父母满意度和母亲抑郁症（爱丁堡产后抑郁量表）的改善也显着更高。在我们的研究人群中，即使在开始治疗的第一周，哭泣时间也显着减少（P <0.01）。我们的结论是L. reuteri（DSM 17938）减少婴儿绞痛期间的每日哭泣时间和母亲抑郁。建议采用L. reuteri可能是减少婴儿绞痛的安全有效的选择。
Infant colic, excessive crying of unknown cause, is a major burden to families and effects about 10-30 % of infants. Despite decades of research, the exact cause and treatment of infant colic has remained elusive. The use of Lactobacillus reuteri (DSM 17938) in infant colic is somewhat controversial and hence, we designed this study to evaluate its efficacy in infantile colic. We recruited predominantly or exclusively breastfed infants, aged less than 4 months in a placebo controlled observational randomized study. Participants' were assigned to receive L. reuteri at a dose 10(8) colony forming units (n = 21) and placebo (n = 21). Placebo was an identical formulation without live micro-organisms. Treatment was given to subjects for 21 days and they were followed for 4 weeks. Treatment success (primary outcome), daily reduction in crying time, parent satisfaction and reduction in maternal depression (secondary outcomes) were assessed at the end of study period. Treatment success was observed in all infants (100 %) of the probiotic group while it was seen in 15.7 % of the placebo group. Mean daily crying time was more significantly reduced to 32.1 +/- A 8.3 min/day (P < 0.01) from 200.9 +/- A 6.3 min/day in the probiotic group as compared to the placebo group (120.6 +/- A 20.0 min/day). Moreover, throughout the study period, parent's satisfaction and improvement in maternal depression (Edinburgh postnatal depression scale) was also significantly higher in the probiotic group. In our study population, reduction in crying time was significant (P < 0.01) even during first week of initiation of therapy. We conclude that L. reuteri (DSM 17938) reduces daily crying time and maternal depression during infantile colic. We suggest L. reuteri may be a safe and efficacious option for reducing infant colic.