Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort.
Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort.
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DOI：
10.1016/j.joca.2008.07.008
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发表时间：
2009-03
影响因子：
7
通讯作者：
OAI Investigator Group
中科院分区：
文献类型：
--
作者：
Wirth W;Hellio Le Graverand MP;Wyman BT;Maschek S;Hudelmaier M;Hitzl W;Nevitt M;Eckstein F;OAI Investigator Group
The Osteoarthritis Initiative (OAI) is aimed at validating (imaging) biomarkers for monitoring progression of knee OA. Here we analyze regional femorotibial cartilage thickness changes over one year using 3 Tesla MRI. Specifically, we tested whether changes in central subregions exceed those in the total cartilage plates. The right knees of a subsample of the OAI progression subcohort (n=156 age 60.9±9.9 y) were studied. 54 participants had definite radiographic OA (KLG 2 or 3) and a BMI>30. Mean and minimal cartilage thickness was determined in subregions of the medial/lateral tibia (MT/LT), and of the medial/lateral weight-bearing femoral condyle (cMF/cLF), after paired (baseline, follow-up) segmentation of coronal FLASHwe images with blinding to the order of acquisition. The central aspect of cMF displayed a 5.8%/2.8% change in mean thickness in the group of 54/156 participants, respectively, with a standardized response mean (SRM) of -0.47/-0.31, whereas cartilage loss in the total cMF was 4.1%/1.9% (SRM -0.49/-0.30). In the central MT, the rate of change was -1.6% /-0.9% and the SRM -0.29/-0.20, whereas for the entire MT the rate was -1.0%/-0.5% and the SRM -0.21/-0.12. Minimal thickness displayed greater rates of change, but lower SRMs than mean thickness. This study shows that the rate of cartilage loss is greater in central subregions than in entire femorotibial cartilage plates. The sensitivity to change in central subregions was higher than for the total cartilage plate in the medial tibia and was similar to the total plate in the medial weight-bearing femur.
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影响因子：
7
作者：
Koo, S;Gold, GE;Andriacchi, TP
通讯作者：
Andriacchi, TP
影响因子：
2.1
作者：
Peterfy, C;Li, J;Genant, HK
通讯作者：
Genant, HK
影响因子：
--
作者：
Raynauld, JP;Martel-Pelletier, J;Pelletier, JP
通讯作者：
Pelletier, JP
影响因子：
5.9
作者：
Kothari, M;Guermazi, A;Peterfy, CG
通讯作者：
Peterfy, CG
影响因子：
10.6
作者：
Wirth, Wolfgang;Eckstein, Felix
通讯作者：
Eckstein, Felix