Hybrid capture 2 viral load and the 2-year cumulative risk of cervical intraepithelial neoplasia grade 3 or cancer
Hybrid capture 2 viral load and the 2-year cumulative risk of cervical intraepithelial neoplasia grade 3 or cancer
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DOI：
10.1016/j.ajog.2004.05.018
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发表时间：
2004-11-01
影响因子：
9.8
通讯作者：
Wheeler, CM
中科院分区：
文献类型：
--
作者：
Castle, PE;Schiffman, M;Wheeler, CM
目的：本研究的目的是确定通过杂交捕获2测定法半定量测量人乳头瘤病毒病毒载量用于组织学宫颈上皮内瘤变3级或癌的风险分层的临床价值。意义不明的非典型细胞和低度鳞状上皮内病变分类研究是一项随机临床试验，5060名妇女随访2年，以评估可疑或轻度异常宫颈细胞学状况的妇女的治疗策略。连续杂交捕获2输出高于阳性阈值的相对光单位/阳性对照的有效性（1.0相对光单位/阳性对照），其是人乳头瘤病毒病毒载量的替代物，用于区分研究期间诊断为宫颈上皮内瘤变3级或癌的杂交捕获2阳性女性与未诊断为宫颈上皮内瘤变3级或癌的女性，结果：相对光单位/阳性对照值并没有进一步区分杂交捕获2阳性妇女与宫颈上皮内瘤变3级或癌与那些小于宫颈上皮内瘤变3级或癌。使用宫颈上皮内瘤变2级或更严重或癌的情况下定义并没有改变我们的findings.Conclusion：不典型细胞的意义不明或低度鳞状上皮内病变宫颈细胞学检查结果的妇女，混合捕获2病毒载量测量并没有提高检测2年累积的宫颈上皮内瘤变3级或癌显着。(C)2004年爱思唯尔公司All rights reserved.
Objective: The purpose of this study was to determine the clinical value of a semiquantitative measure of human papillomavirus viral load by the hybrid capture 2 assay for stratification of the risk of histologic cervical intraepithelial neoplasia grade 3 or carcinoma.Study design: The Atypical Cells of Unknown Significance and Low-Grade Squamous Intraepithelial Lesions Triage Study was a randomized clinical trial of 5060 women with 2 years of follow-up to evaluate treatment strategies for women with equivocal or mildly abnormal cervical cytologic condition. The usefulness of the continuous hybrid capture 2 output relative light units/positive controls that were above the positive threshold (1.0 relative light units/positive controls), which was a surrogate for human papillomavirus viral load, for distinguishing between hybrid capture 2 positive women who were diagnosed with cervical intraepithelial neoplasia grade 3 or carcinoma during the study from those who were not diagnosed with cervical intraepithelial neoplasia grade 3 or carcinoma was examined with the use of receiver-operator characteristic analyses.Results: Relative light units/positive controls values did not further discriminate between hybrid capture 2 positive women with cervical intraepithelial neoplasia grade 3 or carcinoma from those with less than cervical intraepithelial neoplasia grade 3 or carcinoma. The use of a cervical intraepithelial neoplasia grade 2 or more severe or carcinoma case definition did not alter our findings.Conclusion: Among women with atypical cells of unknown significance or low-grade squamous intraepithelial lesion cervical cytologic findings, the hybrid capture 2 viral load measurement did not improve the detection of 2-year cumulative cases of cervical intraepithelial neoplasia grade 3 or carcinoma significantly. (C) 2004 Elsevier Inc. All rights reserved.