ONE-YEAR LONGITUDINAL STUDY OF FATIGUE, COGNITIVE FUNCTIONS, AND QUALITY OF LIFE AFTER ADJUVANT RADIOTHERAPY FOR BREAST CANCER
ONE-YEAR LONGITUDINAL STUDY OF FATIGUE, COGNITIVE FUNCTIONS, AND QUALITY OF LIFE AFTER ADJUVANT RADIOTHERAPY FOR BREAST CANCER
复制标题
DOI：
10.1016/j.ijrobp.2010.06.037
复制
发表时间：
2011-11-01
影响因子：
7
通讯作者：
Joly, Florence
中科院分区：
文献类型：
--
作者：
Noal, Sabine;Levy, Christelle;Joly, Florence
目的：大多数接受辅助化疗(CT)的局限性乳腺癌(LBC)患者在接受放疗(RT)期间或之后都会感到疲倦和生活质量下降。这项纵向研究的目的是比较单纯放疗和放疗后对生活质量的影响。方法和材料：对161例放疗和141例放疗患者在放疗过程中和1年后进行疲劳(主要终点)和认知功能障碍的评估。结果：在基线时，60%的放疗患者表现出疲劳，而放疗患者的疲劳率为33%(P
Purpose: Most patients with localized breast cancer (LBC) who take adjuvant chemotherapy (CT) complain of fatigue and a decrease in quality of life during or after radiotherapy (RT). The aim of this longitudinal study was to compare the impact of RT alone with that occurring after previous CT on quality of life.Methods and Materials: Fatigue (the main endpoint) and cognitive impairment were assessed in 161 CT-RT and 141 RT patients during RT and 1 year later. Fatigue was assessed with Functional Assessment of Cancer Therapy-General questionnaires, including breast and fatigue modules.Results: At baseline, 60% of the CT-RT patients expressed fatigue vs. 33% of the RT patients (p