Implication of pattern-recognition receptors in cardiovascular diseases.
Implication of pattern-recognition receptors in cardiovascular diseases.
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DOI：
10.1089/ars.2014.6184
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发表时间：
2015-04
影响因子：
6.6
通讯作者：
Xiaojie Wang;Fan Yi
中科院分区：
文献类型：
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作者：
Xiaojie Wang;Fan Yi
模式识别受体（PRR）是一个受体家族，用于检测病原体相关分子模式或损伤相关分子模式，启动免疫反应以解决感染和修复受损组织。PRR激活的异常必然导致过度炎症。虽然心血管疾病涉及多种病理生理过程，但最近的研究强调了先天PRR，特别是Toll样受体和核苷酸结合寡聚化结构域样受体在介导炎症反应和心血管功能中的重要性。关键问题PRR在心血管疾病中的功能作用和调节机制在很大程度上仍然是未知的。特别是，存在争议的确定性，这些有害或有益的影响，一些PRR在不同的疾病状态或不同的实验动物模型。考虑到单个PRR调节细胞功能的分子机制是复杂的，并且多个PRR同时或协同激活，更好地理解单个PRR的功能和PRR的相互作用将为通过调节先天免疫系统开发心血管疾病的新疗法提供意想不到的机会。
SIGNIFICANCE Pattern-recognition receptors (PRRs) are a family of receptors that are used to detect pathogen-associated molecular patterns or damage-associated molecular patterns, which initiate immune responses to resolve infections and repair damaged tissues. Abnormalities in PRR activation will unavoidably lead to excessive inflammation. RECENT ADVANCES Although multiple pathophysiological processes are involved in cardiovascular disease, recent studies have highlighted the importance of innate PRRs, in particular, Toll-like receptors and nucleotide-binding oligomerization domain-like receptors, in mediating inflammatory responses and cardiovascular function. CRITICAL ISSUES The functional roles and regulatory mechanisms of PRRs in cardiovascular diseases are still largely unknown. In particular, controversies exist on the certainty of these detrimental or beneficial effects of some PRRs in different diseased states or different experimental animal models. FUTURE DIRECTIONS Considering that the molecular mechanisms for individual PRR to regulate cellular function are complex and multiple PRRs are activated simultaneously or synergistically, a better understanding of the function of individual PRRs and the interplay of PRRs will provide unexpected opportunities to develop new therapies for cardiovascular disease by modulation of an innate immune system.