EXPRESSION AND FUNCTIONAL-SIGNIFICANCE OF AN ADDITIONAL LIGAND FOR CTLA-4
EXPRESSION AND FUNCTIONAL-SIGNIFICANCE OF AN ADDITIONAL LIGAND FOR CTLA-4
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DOI：
10.1073/pnas.90.23.11054
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发表时间：
1993-12-01
影响因子：
11.1
通讯作者：
BLUESTONE, JA
中科院分区：
文献类型：
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作者：
LENSCHOW, DJ;SU, GHT;BLUESTONE, JA
有效的T细胞活化需要抗原/主要组织相容性复合物与一种或多种共刺激分子一起通过T细胞受体复合物接合。最近的研究表明，在大多数抗原呈递细胞上表达的B7分子通过与T细胞上的CD 28相互作用而发挥共刺激分子的功能。用CTLA 4 Ig阻断CD 28/B7相互作用抑制体外T细胞活化并诱导无反应性。我们证明了另一种分子，称为B7-2，在树突状细胞上组成型表达，在B细胞上差异调节，并共刺激应答同种异体抗原的幼稚T细胞。B7-2被脂多糖上调，
Effective T-cell activation requires antigen/major histocompatibility complex engagement by the T-cell receptor complex in concert with one or more costimulatory molecules. Recent studies have suggested that the B7 molecule, expressed on most antigen presenting cells, functions as a costimulatory molecule through its interaction with CD28 on T cells. Blocking the CD28/B7 interaction with CTLA4Ig inhibits T-cell activation in vitro and induces unresponsiveness. We demonstrate that another molecule(s), termed B7-2, is expressed constitutively on dendritic cells, is differentially regulated on B cells, and costimulates naive T cells responding to alloantigen. B7-2 is up-regulated by lipopolysaccharide in