Neonatal capsaicin attenuates mechanical nociception in the rat.
Neonatal capsaicin attenuates mechanical nociception in the rat.
复制标题
新生儿辣椒素可减弱大鼠的机械伤害感受。
DOI：
10.1016/0304-3940(96)12394-6
复制
发表时间：
1996
影响因子：
2.5
通讯作者：
Levine,JD
中科院分区：
文献类型：
--
作者：
Khasar,SG;Levine,JD
The contribution of chemosensitive neurons to mechanical nociception and hyperalgesia was studied by evaluating mechanical nociceptive threshold and the effect of three directly-acting hyperalgesic agents (prostaglandin E2, prostaglandin E1and the A2-adenosine agonist, CGS21680) in rats treated neonatally with capsaicin. Mechanical nociceptive threshold was quantified by the Randall-Selitto paw-withdrawal method. The baseline mechanical paw-withdrawal threshold of the capsaicin-treated rats was 40% higher than that of the untreated rats. In the capsaicin-treated rats mechanical hyperalgesia was not induced by prostaglandin E2, prostaglandin E1or CGS21680. These results are consistent with the suggestion that mechanical nociception and hyperalgesia induced by inflammatory substances is mediated by action on capsaicin-sensitive nociceptors.
