EPIDEMIOLOGIC-STUDY OF PATIENTS WITH SYSTEMIC-SCLEROSIS IN TOKYO
EPIDEMIOLOGIC-STUDY OF PATIENTS WITH SYSTEMIC-SCLEROSIS IN TOKYO
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DOI：
10.1007/bf00371817
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发表时间：
1991-01-01
影响因子：
3
通讯作者：
TAKEHARA, K
中科院分区：
文献类型：
--
作者：
TAMAKI, T;MORI, S;TAKEHARA, K
我们在东京市进行了一项系统性硬化症的流行病学研究，使用了登记接受疑难杂症免费医疗服务的患者的记录。1987年，共有636名患者登记为系统性硬化症患者，我们向每位患者的医生发送了问卷。问卷内容包括患者姓名、性别、年龄、职业、主要症状、治疗及实验室检查结果。我们收到了357份完整的答复，并能够对它们进行分析。我们的研究估计，在1988年1月1日，日本的患病率为每10万人2.1至5.3人。男女比例为14：1。调查时患者的年龄范围为17 - 82岁，平均年龄为51岁，最多的年龄组为50 - 59岁。系统性硬化症的特征性体征如下：近端硬皮病，75%;硬化性指（趾）畸形，91%;凹陷性瘢痕，49%;短舌系带，49%;肺纤维化，45%;弥漫性色素沉着，45%;指骨挛缩，35%。雷诺现象出现在93%的患者中，并且是59%病例的初始症状。在特异性抗核抗体方面，抗着丝粒抗体的存在率为19%，抗拓扑异构酶I抗体的存在率为27%。
We conducted an epidemiological study of systemic sclerosis in the city of Tokyo using the records of patients who had been registered to receive free medical service for intractable diseases. A total of 636 patients were registered as having systemic sclerosis in 1987, and we sent questionnaires to the doctor of each patient. The contents of the questionnaires included the patient's name, sex, age, occupation, major symptoms, therapy and laboratory findings. We received 357 completed replies, and were able to analyse them. Our study estimated that at 1 January 1988 the prevalence rate in Japan was between 2.1 and 5.3 per 100 000. The male/female ratio was 14:1. The ages of the patients when surveyed ranged from 17 to 82 years, with a mean age of 51 years, peaking with the most numerous group being 50 - 59 years. The characteristic signs of systemic sclerosis were as follows: proximal scleroderma, 75%; sclerdactyly, 91%; pitting scars, 49%; short sublingual frenulum, 49%; pulmonary fibrosis, 45%; diffuse pigmentation, 45%; and phalangeal contracture, 35%. Raynaud's phenomenon was present in 93% of patients, and was the initial symptom in 59% of cases. With respect to specific antinuclear antibodies, anticentromere antibody was present in 19% and antitopoisomerase I antibody was present in 27%.