Reevaluation of Histamine in Implantation
Reevaluation of Histamine in Implantation
复制标题
植入中组胺的重新评估
DOI：
10.1007/978-94-011-7855-6_14
复制
发表时间：
1980
期刊：
影响因子：
1.9
通讯作者：
D. Johnson
中科院分区：
文献类型：
--
作者：
S. Dey;D. Johnson
妊娠着床前的生化和生理事件，以及胚泡的着床，都依赖于精确的激素平衡，而激素平衡是由卵巢孕酮和雌激素调节的。尽管进行了大量研究，但仍不清楚雌激素如何启动蜕膜化或在孕激素启动的子宫中着床。伴随着胚泡附着部位子宫间质毛细血管通透性增加的局部炎症反应被认为是最早可识别的事件之一，也是着床的先决条件(Minchoyos，1967；Finn&McLaren，1967；McLaren，1968)。基于这一点和其他几个发现，有人提出雌激素释放组胺(一种血管活性胺)是诱导着床的原因(纳尔班多夫，1971)。然而，谢列斯尼亚克的组胺诱导蜕膜化或植入的理论受到了许多研究人员的挑战，并没有得到普遍的接受(DeFeo，1967)。
The biochemical and physiological events during the preimplantation stages of pregnancy, as well as the implantation of the blastocyst, depend upon a precise hormonal balance which is regulated by ovarian progesterone and estro-gen. Despite considerable research, it is still not clear how estrogen initiates decidualization or implantation in the progesterone primed uterus. A local pro-inflammatory reaction accompanied by an increase in uterine stromal capillary permeability at the site of blastocyst attachment has been considered to be one of the earliest discernible events and a prerequisite for implantation (Psychoyos, 1967; Finn & McLaren, 1967; McLaren, 1968). On the basis of this and several other findings, it was proposed that the release of histamine, a vasoactive amine, by estrogen is responsible for induction of implantation (reviewed by Nalbandov, 1971). However, Shelesnyak’s theory of histamine induction of decidualization or implantation was challenged by many investigators and did not gain general acceptance (reviewed by DeFeo, 1967).