Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults.
Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults.
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DOI：
10.1186/s13195-017-0271-9
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发表时间：
2017-07-03
期刊：
影响因子：
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通讯作者：
Peskind ER
中科院分区：
文献类型：
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作者：
Li G;Shofer JB;Petrie EC;Yu CE;Wilkinson CW;Figlewicz DP;Shutes-David A;Zhang J;Montine TJ;Raskind MA;Quinn JF;Galasko DR;Peskind ER
本研究旨在评估认知正常成年人在整个生命周期中阿尔茨海默病（AD）和脑血管损伤的脑脊液（CSF）生物标志物浓度的性别和APOE基因型相关差异。在331名年龄在21至100岁之间的参与者中测量了CSF淀粉样蛋白β 1 -42（Aβ42）、磷酸化tau-181（p-tau 181）和总tau。对249名年龄在50岁至100岁之间的参与者进行了CSF E-选择素和血管细胞粘附蛋白1（VCAM 1）的测定。CSF总tau和p-tau 181在成年期内随年龄增加（p < 0.01），这些增加没有性别差异。CSF Aβ42浓度因年龄、性别和APOE基因型而异（年龄×性别× ε4的相互作用，p = 0.047）。CSF VCAM 1，而不是E-选择素，随着年龄的增长而增加（p < 0.01），但两者在男性中均高于女性（p < 0.01）。女性APOE-ε4携带者在50岁以后出现AD的风险更高。相比之下，男性在中年和老年早期可能会经历相对较高的脑血管损伤率。本文的在线版本（doi：10.1186/s13195-017-0271-9）包含补充材料，可供授权用户使用。
This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) and cerebrovascular injury across the life span of cognitively normal adults. CSF amyloid beta1–42 (Aβ42), phospho-tau-181 (p-tau181), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF E-selectin and vascular cell adhesion protein 1 (VCAM1) were measured in 249 participants who were between the ages of 50 and 100. CSF total tau and p-tau181 increased with age over the adult life span (p < 0.01) with no gender differences in those increases. CSF Aβ42 concentration varied according to age, gender, and APOE genotype (interaction of age × gender × ε4, p = 0.047). CSF VCAM1, but not E-selectin, increased with age (p < 0.01), but both were elevated in men compared to women (p < 0.01). Female APOE-ε4 carriers appear at higher risk for AD after age 50. In contrast, men may experience a relatively higher rate of cerebrovascular injury in middle and early old age. The online version of this article (doi:10.1186/s13195-017-0271-9) contains supplementary material, which is available to authorized users.