Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae
Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae
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DOI：
10.1093/jac/47.5.651
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发表时间：
2001-05-01
影响因子：
5.2
通讯作者：
Shafer, WM
中科院分区：
文献类型：
--
作者：
Zarantonelli, L;Borthagaray, G;Shafer, WM
在乌拉圭获得的淋病奈瑟氏菌临床分离株对阿奇霉素敏感性的筛选过程中，我们注意到，由于 mtr(CDE) 编码的流入泵系统，大约 10% 的检查菌株对阿奇霉素和红霉素的敏感性降低，但仍然对 Triton X-100 敏感。我们现在报道，这些分离株之一的 mtr(R) 启动子区域含有二核苷酸介导这种耐药表型的插入（TT）。
During a screen of Neisseria gonorrhoeae clinical isolates obtained in Uruguay for susceptibility to azithromycin, we noticed that approximately 10% of the strains examined displayed decreased susceptibility to azithromycin and erythromycin due to the mtr(CDE)-encoded afflux pump system, but remained susceptible to Triton X-100, We now report that the mtr(R) promoter region of one of these isolates contains a dinucleotide insertion (TT) that mediates this resistance phenotype.