Gestational Diabetes Mellitus Risk in Pregnant Women With Systemic Lupus Erythematosus.
Gestational Diabetes Mellitus Risk in Pregnant Women With Systemic Lupus Erythematosus.
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DOI：
10.3899/jrheum.210087
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Arkema EV
中科院分区：
文献类型：
--
作者：
Gernaat SAM;Simard JF;Wikström AK;Svenungsson E;Arkema EV
通过比较系统性红斑狼疮（SLE）妇女与一般人群对照的妊娠，探讨妊娠期糖尿病（GDM）与SLE相关的风险。我们在瑞典医学出生登记（MBR; 2006-2016）中确定了SLE女性和一般人群对照的单胎妊娠，从基于人群的登记联系SLINK（1987-2012）中抽样。SLE定义为在国家患者登记册（NPR）和MBR中≥2次国际疾病分类（ICD）编码的访视，妊娠前≥1次访视。GDM定义为NPR或MBR中≥1次ICD编码的访视。在处方药物登记处确定了妊娠前6个月和妊娠期间的糖皮质激素（GC）和羟氯喹（HCQ）分配。采用改良Poisson回归模型估计GDM与SLE相关的风险比和95%置信区间（RR; 95%CI），按胎次分层，并根据母亲分娩时的年龄、出生年份和肥胖进行调整。我们确定了695例SLE妊娠，包括18例（2.6%）GDM，4,644例非SLE妊娠，包括65例（1.4%）GDM。与SLE相关的GDM的校正RR在首次分娩时为1.11（95%CI 0.38-3.27），在所有分娩时为2.03（95%CI 1.21-3.40）。在SLE妊娠中，7/306（2.3%）例妊娠前和/或妊娠期间有≥1次GC，11/389（2.8%）例无GC，7/287（2.4%）例妊娠前和/或妊娠期间有≥1次HCQ，11/408（2.7%）例无HCQ。当观察所有分娩时，SLE与GDM的风险增加两倍相关。GDM的发生率在GC或HCQ之间没有差异。
To investigate the risk of gestational diabetes mellitus (GDM) associated with systemic lupus erythematosus (SLE) by comparing pregnancies in women with SLE to general population controls. We identified singleton pregnancies among women with SLE and general population controls in the Swedish Medical Birth Register (MBR; 2006–2016), sampled from the population-based register linkage SLINK (1987–2012). SLE was defined by ≥2 International Classification of Diseases (ICD)-coded visits in the National Patient Register (NPR) and MBR, with ≥1 visit before pregnancy. GDM was defined by ≥1 ICD-coded visit in the NPR or MBR. Glucocorticoid (GC) and hydroxychloroquine (HCQ) dispensations 6 months before and during pregnancy were identified in the Prescribed Drug Register. Risk ratios and 95% confidence intervals (RRs; 95% CI) of GDM associated with SLE were estimated using modified Poisson regression models, stratified by parity and adjusted for maternal age at delivery, year of birth, and obesity. We identified 695 SLE pregnancies including 18 (2.6%) with GDM and 4,644 non-SLE pregnancies including 65 (1.4%) with GDM. Adjusted RRs of GDM associated with SLE were 1.11 (95% CI 0.38–3.27) for first deliveries and 2.03 (95% CI 1.21–3.40) for all deliveries. Among SLE pregnancies, GDM occurred in 7/306 (2.3%) with ≥1 GC before and/or during pregnancy, 11/389 (2.8%) without GC, 7/287 (2.4%) with ≥1 HCQ before and/or during pregnancy, and in 11/408 (2.7%) without HCQ. When looking at all deliveries, SLE was associated with a two-fold higher risk of GDM. GDM occurrence did not differ by GC or HCQ.
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DOI：
10.3899/jrheum.090994
发表时间：
2010-06
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Penn SK;Kao AH;Schott LL;Elliott JR;Toledo FG;Kuller L;Manzi S;Wasko MC
通讯作者：
Wasko MC
影响因子：
2.9
作者：
Wu J;Ma J;Bao C;Di W;Zhang WH
通讯作者：
Zhang WH
影响因子：
2.8
作者：
MacDonald SC;Hernán MA;McElrath TF;Hernández-Díaz S
通讯作者：
Hernández-Díaz S
影响因子：
81.5
作者：
McIntyre, H. David;Catalano, Patrick;Damm, Peter
通讯作者：
Damm, Peter
影响因子：
27.4
作者：
Andreoli L;Bertsias GK;Agmon-Levin N;Brown S;Cervera R;Costedoat-Chalumeau N;Doria A;Fischer-Betz R;Forger F;Moraes-Fontes MF;Khamashta M;King J;Lojacono A;Marchiori F;Meroni PL;Mosca M;Motta M;Ostensen M;Pamfil C;Raio L;Schneider M;Svenungsson E;Tektonidou M;Yavuz S;Boumpas D;Tincani A
通讯作者：
Tincani A