Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions.
Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions.
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DOI：
10.3390/cancers9020019
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发表时间：
2017-02-18
期刊：
影响因子：
5.2
通讯作者：
Robinson DJ
中科院分区：
文献类型：
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作者：
van Straten D;Mashayekhi V;de Bruijn HS;Oliveira S;Robinson DJ
光动力疗法 (PDT) 是一种临床批准的癌症疗法，基于光激活分子或光敏剂、光和分子氧之间的光化学反应。当这三种无害的成分同时存在时，就会形成活性氧。这些可以直接损害细胞和/或脉管系统，并诱导炎症和免疫反应。 PDT 是一个两阶段程序，首先使用光敏剂，然后进行局部定向光照，目的是限制肿瘤破坏。自 30 多年前获得监管部门批准以来，PDT 已成为众多研究的主题，并已被证明是一种有效的癌症治疗形式。本综述概述了过去 10 年进行的临床试验，说明了 PDT 如何在当今的临床中应用。此外，还提供了正在进行的临床试验和最新临床前研究的示例，以表明 PDT 在不久的将来和遥远的将来的发展方向。尽管临床上取得了成功，但 PDT 目前在临床上仍未得到充分利用。我们还讨论了阻碍探索这种有效疗法的因素，以及应该做出哪些改变才能使其成为患者更有效、更广泛的选择。
Photodynamic therapy (PDT) is a clinically approved cancer therapy, based on a photochemical reaction between a light activatable molecule or photosensitizer, light, and molecular oxygen. When these three harmless components are present together, reactive oxygen species are formed. These can directly damage cells and/or vasculature, and induce inflammatory and immune responses. PDT is a two-stage procedure, which starts with photosensitizer administration followed by a locally directed light exposure, with the aim of confined tumor destruction. Since its regulatory approval, over 30 years ago, PDT has been the subject of numerous studies and has proven to be an effective form of cancer therapy. This review provides an overview of the clinical trials conducted over the last 10 years, illustrating how PDT is applied in the clinic today. Furthermore, examples from ongoing clinical trials and the most recent preclinical studies are presented, to show the directions, in which PDT is headed, in the near and distant future. Despite the clinical success reported, PDT is still currently underutilized in the clinic. We also discuss the factors that hamper the exploration of this effective therapy and what should be changed to render it a more effective and more widely available option for patients.