Lead-induced hypertension - Interplay of nitric oxide and reactive oxygen species
Lead-induced hypertension - Interplay of nitric oxide and reactive oxygen species
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DOI：
10.1161/01.hyp.30.6.1487
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发表时间：
1997-12-01
期刊：
影响因子：
8.3
通讯作者：
Vaziri, ND
中科院分区：
文献类型：
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作者：
Gonick, HC;Ding, YX;Vaziri, ND
与配对的 Sprague-Dawley 对照大鼠相比，用低铅（0.01% 醋酸铅）治疗 3 个月的大鼠平均血压升高。在这些大鼠中，血浆和尿液内皮素-1和-3的测量显示，内皮素-3的血浆浓度和尿排泄量在3个月后显着增加（血浆：铅组，31.8+2.2，对比对照组，23.0+1.7 pg/mL，P
An elevation of mean blood pressure was found in rats treated with low lead (0.01% lead acetate) for 3 months, as contrasted to paired Sprague-Dawley control rats. In these rats, measurement of plasma and urine endothelins-1 and -3 revealed that plasma concentration and urinary excretion of endothelin-3 increased significantly after 3 months (plasma: lead group, 31.8+2.2, versus controls, 23.0+1.7 pg/mL, P