Microvascular imaging of asymptomatic MCA steno-occlusive patients using ultra-high-field 7T MRI
Microvascular imaging of asymptomatic MCA steno-occlusive patients using ultra-high-field 7T MRI
复制标题
DOI：
10.1007/s00415-012-6604-5
复制
发表时间：
2013-01-01
影响因子：
6
通讯作者：
Kim, Young-Bo
中科院分区：
文献类型：
--
作者：
Cho, Zang-Hee;Lee, Yeong-Bae;Kim, Young-Bo
临床医生经常遇到颅内动脉严重狭窄闭塞而无临床症状的患者。本研究旨在探讨7 T磁共振血管造影（MRA）能否改善无症状大脑中动脉（MCA）狭窄闭塞患者的微血管显示，并为临床症状的诊断提供可能的线索。所有确诊为重度MCA狭窄闭塞的患者均行7 T MRA检查。其中3例还接受了常规血管造影术（TFCA）。测量狭窄闭塞的大脑中动脉（MCA）和大脑后动脉（PCA）分支周围的血管密度，并分析7 T和3 T MRA数据中位数的差异。7 T MRA显示了大量常规MRA无法显示的微血管。这些7 T MRA图像也与侵入性常规血管造影（TFCA）获得的图像相当。7 T MRA观察到的血管密度中位数显著高于3 T MRA（狭窄闭塞MCA在7 T时为5.28 vs. 3 T时为1.45，p = 0.012;正常PCA在7 T时为3.39 vs. 3 T时为3.32，p = 0.093）。超高场7 T MRA是一种完全无创的血管造影技术，能够显示常规MRA通常难以显示的微血管循环。因此，这种可视化技术，可以提供一个重要的途径狭窄闭塞的诊断，以及寻找的作用，微血管，特别是侧支，在保持正常的血液循环的患者无症状的MCA狭窄闭塞。
It is common that physicians are faced with patients who have severe steno-occlusion of intracranial arteries in the absence of clinical symptoms. This study is to determine whether a 7T magnetic resonance angiogram (MRA) could provide the improved depiction of microvessels of asymptomatic patients with steno-occlusive middle cerebral artery (MCA) and possible clues for diagnosis of their clinical symptoms. All the patients who were identified as severe MCA steno-occlusions underwent a 7T MRA study. Three of these also underwent conventional angiography (TFCA). The vascular densities around the steno-occlusive MCA and posterior cerebral artery (PCA) branches as control vessels were measured and the difference between the median values of 7T and 3T MRA data was also analyzed. The results of 7T MRA revealed numerous microvessels not visible by conventional MRA. These 7T MRA images were also comparable to those obtained by an invasive conventional angiography (TFCA). The median values of vascular densities observed by 7T MRA were significantly higher than those by 3T MRA (5.28 at 7T vs. 1.45 at 3T for steno-occlusive MCA, p = 0.012, while 3.39 at 7T vs. 3.32 at 3T for normal PCA, p = 0.093). Ultra-high-field 7T MRA is a totally noninvasive angiographic technique that is capable of visualizing microvascular circulation that is usually difficult with conventional MRA. This visualization technique, therefore, could provide an important avenue on the diagnosis of steno-occlusion as well as the search of the roles of the microvessel, especially collaterals, in the preservation of normal blood circulation in patients with asymptomatic MCA steno-occlusion.