Reduction of brown fat 2-deoxy-2-[F-18] fluoro-D-glucose uptake by controlling environmental temperature prior to positron emission tomography scan
Reduction of brown fat 2-deoxy-2-[F-18] fluoro-D-glucose uptake by controlling environmental temperature prior to positron emission tomography scan
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DOI：
10.1007/s11307-005-0030-3
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Majd, M
中科院分区：
文献类型：
--
作者：
Garcia, CA;Van Nostrand, D;Majd, M
正电子发射断层扫描（PET）中棕色脂肪对2-脱氧-2-[F-18]氟-D-葡萄糖（FDG）的摄取限制了评估癌症的能力。苯二氮卓类、普萘洛尔和利血平等药物已被提议减少这种摄取，但这些研究要么是小型临床试验，要么是临床前试验。作为替代方案，我们评估了控制患者环境温度对FDG棕色脂肪摄取的影响。方法：从2002年1月1日至2004年11月30日，确定了以下患者：（1）颈部/椎旁区域FDG摄取模式提示棕色脂肪，（2）在控制患者环境温度后重复FDG-PET扫描，和（3）通过其他诊断方法没有颈部/椎旁区域癌症的证据。对于后续PET扫描，所有患者都穿着保暖的衣服，并在运送到我们的设施期间避免暴露于冷空气。到达后，患者在FDG注射前以及摄取阶段被保持在单独的温度控制室（至少75华氏度）15分钟至2小时。四名医生通过半定量的放射性视觉分级（0 =背景，1+ =背景但<肝脏，2+ =等于肝脏，3+ >肝脏），盲法和回顾性地评估了所有初始和温度控制的PET扫描中颈部和椎旁区域的FDG摄取。在左侧和右侧颈部区域确定最大SUV的变化。数据采用双尾t检验进行评价。结果：10例患者符合上述标准。中位年龄为32岁，范围为11-58岁。在比较初始PET扫描与温控PET扫描的颈部和椎旁区域的FDG半定量摄取和SUV时，平均减少量和减少量的标准差显示出统计学显著性降低，P值范围为< 0.02至<0.001。结论：在给药前和摄取阶段控制患者的环境温度可以显著降低颈部和椎旁区域棕色脂肪中的FDG摄取。进一步的研究是必要的，以确定最有效的协议，以控制病人的环境温度，以尽量减少棕色脂肪的吸收。
Brown fat uptake of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) on a positron emission tomography (PET) scan limits the ability to assess for cancer. Drugs such as benzodiazepine, propranolol, and reserpine have been proposed to reduce this uptake, but the studies have been either small clinical or preclinical trials. As an alternative, we evaluated the effect of controlling the patient's environmental temperature on brown fat uptake of FDG.Method: From January 1, 2002 to November 30, 2004, patients were identified who had (1) a pattern of FDG uptake in the neck/paravertebral areas suggestive of brown fat, (2) a repeat FDG-PET scan after control of the patient's environmental temperature, and (3) no evidence of cancer in the neck/paravertebral areas by other diagnostic methods. For the follow-up PET scan, all patients wore warm clothing and avoided exposure to cold air during their transit to our facility. After arrival, patients were kept in a separate temperature-control led room (at least 75 degrees F) for 15 minutes to two hours before FDG injection as well as during the uptake phase. Four physicians blindly and retrospectively assessed the FDG uptake in the neck and paravertebral regions on all initial and temperature-control led PET scans by visually grading the radioactivity on a semiquantitative scale (0 = background, 1+ = background but < liver, 2+ = equal to liver, 3+ > liver). The changes in maximal SUVs were determined in the left and right neck region. Data were evaluated using a two-tail t-test.Results: Ten patients met the above criteria. The median age was 32 years with a range of 11-58 years. In comparing the semiquantitative uptake and the SUVs of FDG in the neck and paravertebral areas on the initial PET scan to the temperature-controlled PET scan, the mean decrease and the standard deviation of the decrease demonstrated a statistically significant decrease in with P values range from < 0.02 to < 0.001.Conclusion: Controlling the patient's environmental temperature prior to the dosing and during the uptake phase can significantly reduce FDG uptake in brown fat in the neck and paravertebral areas. Further studies are warranted to determine the most effective protocol to control the patient's environmental temperature in order to minimize brown fat uptake.