Effect of Obesity on Prognosis After Early-Stage Breast Cancer
Effect of Obesity on Prognosis After Early-Stage Breast Cancer
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DOI：
10.1200/jco.2010.29.7614
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发表时间：
2011-01-01
影响因子：
45.3
通讯作者：
Cold, Soren
中科院分区：
文献类型：
--
作者：
Ewertz, Marianne;Jensen, Maj-Britt;Cold, Soren
PurposeThis study was performed to characterize the impact of obesity on the risk of breast cancer recurrence and death as a result of breast cancer or other causes relation to adjuvant treatment.Patients and MethodsInformation on body mass index（BMI）at diagnosis was available for 18，967 of 53（35%），1977年至2006年期间，丹麦816例接受早期乳腺癌治疗的女性，对首次事件（局部复发和远处转移）进行了长达10年的完整随访，并对死亡进行了长达30年的随访。所有患者的预后因素和辅助治疗信息均可用。单变量分析用于比较已知预后因素与根据BMI分类的复发或死亡风险的相关性。结果BMI ≥ 30 kg/m2的患者与BMI <25 kg/m2的患者相比，年龄大，诊断时病情较重（P <0.05），BMI ≥ 30 kg/m2的患者与BMI <25 kg/m2的患者相比，年龄大，诊断时病情较重（P <0.05），BMI ≥ 30 kg/m2的患者与BMI <25 kg/m2的患者相比，诊断时病情较重（P <0.05）。
PurposeThis study was performed to characterize the impact of obesity on the risk of breast cancer recurrence and death as a result of breast cancer or other causes in relation to adjuvant treatment.Patients and MethodsInformation on body mass index (BMI) at diagnosis was available for 18,967 (35%) of 53,816 women treated for early-stage breast cancer in Denmark between 1977 and 2006 with complete follow-up for first events (locoregional recurrences and distant metastases) up to 10 years and for death up to 30 years. Information was available on prognostic factors and adjuvant treatment for all patients. Univariate analyses were used to compare the associations of known prognostic factors and risks of recurrence or death according to BMI categories. Cox proportional hazards regression models were used to assess the influence of BMI after adjusting for other factors.Results Patientswith a BMI of 30 kg/m(2) or more were older and had more advanced disease at diagnosis compared with patients with a BMI below 25 kg/m2 (P