Three-dimensional electrical impedance tomography
Three-dimensional electrical impedance tomography
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DOI：
10.1038/380509a0
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发表时间：
1996-04-11
期刊：
影响因子：
64.8
通讯作者：
Brown, BH
中科院分区：
文献类型：
--
作者：
Metherall, P;Barber, DC;Brown, BH
哺乳动物组织的电阻率变化很大(1-5)，并与生理功能有关(6-8)。电阻抗断层扫描(EIT)可以用来探测活体内的这种变化，并提供了一种非侵入性的方法来成像人体内部电导率的分布(9-11)。但EIT的计算复杂性具有严重的实际局限性，以往的工作仅限于将图像重建视为本质上的二维问题(10，12)。这种简化可以显著限制EIT的成像能力，因为用于确定电导率变化的电流一般不限于二维平面(13)，一些研究已经尝试了三维EIT图像重建(14，15)，但尚未成功地产生适合临床应用的质量的图像。在这里，我们报告了一种成像能力大大提高的三维EIT系统的开发，它结合了我们的电极数据采集器(16)和定制的矩阵求逆技术。我们的结果证明了EIT在临床应用中的实际潜力，例如肺或脑成像和诊断筛查。
THE electrical resistivity of mammalian tissues varies widely(1-5) and is correlated with physiological function(6-8). Electrical impedance tomography (EIT) can be used to probe such variations in vivo, and offers a non-invasive means of imaging the internal conductivity distribution of the human body(9-11). But the computational complexity of EIT has severe practical limitations, and previous work has been restricted to considering image reconstruction as an essentially two-dimensional problem(10,12). This simplification can limit significantly the imaging capabilities of EIT, as the electric currents used to determine the conductivity variations will not in general be confined to a two-dimensional plane(13), A few studies have attempted three-dimensional EIT image reconstruction(14,15), but have not yet succeeded in generating images of a quality suitable for clinical applications. Here we report the development of a three-dimensional EIT system with greatly improved imaging capabilities, which combines our 64-electrode data-collection apparatus(16) with customized matrix inversion techniques. Our results demonstrate the practical potential of EIT for clinical applications, such as lung or brain imaging and diagnostic screenings.