Time resolved contrast enhanced intracranial MRA using a single dose delivered as sequential injections and highly constrained projection reconstruction (HYPR CE).
Time resolved contrast enhanced intracranial MRA using a single dose delivered as sequential injections and highly constrained projection reconstruction (HYPR CE).
复制标题
使用单剂量顺序注射和高度约束投影重建 (HYPR CE) 进行时间分辨对比增强颅内 MRA。
DOI：
10.1002/mrm.22792
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发表时间：
2011
影响因子：
3.3
通讯作者：
Turski,Patrick
中科院分区：
文献类型：
--
作者：
Wu,Yijing;Johnson,Kevin;Kecskemeti,StevenR;Wang,Kang;Wieben,Oliver;Aagaard-Kienitz,BeverlyL;Rowley,Howard;Korosec,FrankR;Mistretta,Charles;Turski,Patrick
由于需要快速成像和高空间分辨率，时间分辨对比增强脑磁共振血管造影术具有挑战性。此外，无论采集速度和重建窗口如何，静脉内造影剂团在通过心脏和肺时的显著分散都会增加动脉和静脉结构之间的重叠。提出了一种创新技术，将单剂量造影剂分为两次注射。最初，在造影剂的第一次通过期间，使用少量造影剂（2-3 mL）以高帧率（2帧/秒）采集时间分辨加权图像。剩余的造影剂用于获得高分辨率全脑对比增强（CE）磁共振血管造影（0.57 × 0.57 × 1 mm 3），用作局部高度约束投影重建（HYPR LR）重建的空间约束。HYPR重建后的动态图像（HYPR CE）具有较高的时间和空间分辨率。此外，对比动力学的研究表明，用于第一次注射的减少的对比体积的较短的团注长度显著改善了动脉和静脉分离。Magn Reson Med，2011年。© 2011 Wiley利斯公司
Time‐resolved contrast‐enhanced magnetic resonance angiography of the brain is challenging due to the need for rapid imaging and high spatial resolution. Moreover, the significant dispersion of the intravenous contrast bolus as it passes through the heart and lungs increases the overlap between arterial and venous structures, regardless of the acquisition speed and reconstruction window. An innovative technique is presented that divides a single dose contrast into two injections. Initially a small volume of contrast material (2–3 mL) is used to acquiring time‐resolved weighting images with a high frame rate (2 frames/s) during the first pass of the contrast agent. The remaining contrast material is used to obtain a high resolution whole brain contrast‐enhanced (CE) magnetic resonance angiography (0.57 × 0.57 × 1 mm3) that is used as the spatial constraint for Local Highly Constrained Projection Reconstruction (HYPR LR) reconstruction. After HYPR reconstruction, the final dynamic images (HYPR CE) have both high temporal and spatial resolution. Furthermore, studies of contrast kinetics demonstrate that the shorter bolus length from the reduced contrast volume used for the first injection significantly improves the arterial and venous separation. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.