Brain tumor imaging with 99mTc-tetrofosmin:: comparison with 201Tl, 99mTc-MIBI, and 18F-fluorodeoxyglucose
Brain tumor imaging with 99mTc-tetrofosmin:: comparison with 201Tl, 99mTc-MIBI, and 18F-fluorodeoxyglucose
复制标题
DOI：
10.1023/a:1006391701818
复制
发表时间：
2000-01-01
影响因子：
3.9
通讯作者：
Kim, JH
中科院分区：
文献类型：
--
作者：
Choi, JY;Kim, SE;Kim, JH
本研究的目的是评估锝-99m-替曲膦 (Tc-99m-TF) 预测肿瘤恶性肿瘤的能力，并将其摄取量与铊-201 (Tl-201)、锝-99m-六基-2-甲氧基异丁基异腈 (Tc-99m-MIBI) 和氟-18-氟脱氧葡萄糖进行比较(F-18-FDG) 在脑肿瘤中的应用。对 22 名脑肿瘤患者和 3 名健康对照者进行了 Tc-99m-TF 单光子发射计算机断层扫描 (SPECT) 成像。部分患者接受了 Tl-201 (n = 12) 和 Tc-99m-MIBI SPECT (n = 14) 以及 F-18-FDG 正电子发射断层扫描 (PET) (n = 12)。分别计算SPECT和PET图像中肿瘤与对侧正常组织的放射性比值（T/N）和肿瘤与对侧白质的比值（T/WM）。在健康对照中，仅在头皮、脉络丛和垂体中观察到 Tc-99m-TF 摄取，但在正常脑实质中未观察到。低级别胶质瘤中的 TF T/N (2.8 +/- 0.4) 显着低于高级别胶质瘤 (22.5 +/- 29.8) 和恶性非胶质瘤 (8.3 +/- 2.8)，且无重叠值（分别为 p = 0.003 和 p = 0.014）。 TF T/N 与 MIBI T/N (p = 0.92, p = 0.001)、T1 T/N (p = 0.72, p = 0.017) 和 FDG T/WM (p = 0.65, p = 0.031) 显着相关。线性回归分析中 TF T/N 和 MIBI T/N 值非常一致（MIBI T/N = -0.63 + 0.97 x TF T/N）。这些初步结果表明，Tc-99m-TF SPECT 成像可能有助于脑肿瘤的非侵入性分级。他们还表明，Tc-99m-TF 和 Tc-99m-MIBI 可能通过类似的机制或与类似的肿瘤细胞增殖过程相关，在脑肿瘤中积累。
The purpose of the present study was to assess the ability of technetium-99m-tetrofosmin (Tc-99m-TF) to predict tumor malignancy and to compare its uptake with that of thallium-201 (Tl-201), technetium-99m-hexakis-2-methoxyisobutyl isonitrile (Tc-99m-MIBI) and fluorine-18-fluorodeoxyglucose (F-18-FDG) in brain tumors. Tc-99m-TF single-photon emission computed tomography (SPECT) imaging was performed in 22 patients with brain tumors and 3 healthy controls. Some of the patients underwent Tl-201 (n = 12) and Tc-99m-MIBI SPECT (n = 14) and F-18-FDG positron emission tomography (PET) (n = 12). The radioactivity ratio of tumor to contralateral normal tissue (T/N) and the ratio of tumor to contralateral white matter (T/WM) were calculated in SPECT and PET images, respectively. In healthy controls, Tc-99m-TF uptake was seen only in scalp, in the choroid plexus and pituitary gland, but not in normal cerebral parenchyma. TF T/N in low grade gliomas (2.8 +/- 0.4) was significantly lower,than that in high grade gliomas (22.5 +/- 29.8) and malignant non-gliomas (8.3 +/- 2.8) without overlap of values (p = 0.003 and p = 0.014, respectively). TF T/N was significantly correlated with MIBI T/N (p = 0.92, p = 0.001), T1 T/N (p = 0.72, p = 0.017), and FDG T/WM (p = 0.65, p = 0.031). There was an excellent agreement between TF T/N and MIBI T/N values on linear regression analysis (MIBI T/N = -0.63 + 0.97 x TF T/N). These preliminary results indicate that SPECT imaging with Tc-99m-TF may be useful for the non-invasive grading of brain tumors. They also suggest that Tc-99m-TF and Tc-99m-MIBI may accumulate in brain tumors by a similar mechanism or in relation to a similar process of tumor cell proliferation.