The interleukin 2 gene is expressed in the syncytiotrophoblast of the human placenta.
The interleukin 2 gene is expressed in the syncytiotrophoblast of the human placenta.
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白细胞介素2基因在人胎盘的合体滋养层中表达。
DOI：
10.1073/pnas.86.2.656
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发表时间：
1989
影响因子：
11.1
通讯作者：
Ilan,J
中科院分区：
文献类型：
--
作者：
Boehm,KD;Kelley,MF;Ilan,J;Ilan,J
淋巴因子白介素2是一种重要的免疫系统调节性糖多肽。它是由抗原或有丝分裂原刺激的T淋巴细胞产生的，是活化T淋巴细胞增殖或克隆性扩增所必需的。在这份报告中，通过RNA转移印迹杂交证明，人胎盘的Poly(A)+RNA群体包含一个0.85kb的RNA转录本，该转录本与人白细胞介素2cDNA探针特异杂交。用原位杂交组织化学方法进一步证明，白介素2RNA转录本主要定位于人胎盘的合胞体(合体滋养层)。建议并讨论了合体滋养层细胞产生的白介素2的可能作用。
The lymphokine interleukin 2 is an important immune system regulatory glycopolypeptide. It is produced by antigen- or mitogen-stimulated T lymphocytes and is required for the proliferation or clonal expansion of activated T lymphocytes. In this report, it is demonstrated by RNA transfer blot hybridization that the poly(A)+ RNA population of the human placenta contains a 0.85-kilobase RNA transcript that specifically hybridizes to a human interleukin 2 cDNA probe. By using hybridization histochemistry in situ, it is further shown that interleukin 2 RNA transcripts are localized, primarily, to the syncytial (syncytiotrophoblast) layer of the human placenta. Possible roles for syncytiotrophoblast-produced interleukin 2 are suggested and discussed.