5-HT1A receptor-mediated apoptosis: death by JNK?
5-HT1A receptor-mediated apoptosis: death by JNK?
复制标题
5-HT1A 受体介导的细胞凋亡：JNK 导致死亡？
DOI：
10.1016/j.bbamcr.2007.01.003
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Meller,Emanuel
中科院分区：
文献类型：
--
作者：
Meller,Emanuel
5-HT 1A受体激动剂作为脑卒中和创伤性脑损伤的神经保护剂的潜在用途越来越受到关注。然而，一项使用重组5-HT 1A受体细胞系的新研究表明，这些激动剂可能促进和抑制凋亡反应。由于异源表达的受体可能偶联混杂不适当的信号转导途径，结果应谨慎解释。
There is growing interest in the potential use of 5-HT1Areceptor agonists as neuroprotective agents in stroke and tramautic brain injury. However, a new study using a recombinant 5-HT1Areceptor cell line suggests that these agonists may promote as well as inhibit apoptotic responses. Because heterologously expressed receptors may couple promiscuously to inappropriate signal transduction pathways, the results should be interpreted with caution.