Wavelength of light and photophobia in inherited retinal dystrophy
Wavelength of light and photophobia in inherited retinal dystrophy
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遗传性视网膜营养不良中的光波长和畏光
DOI：
10.1038/s41598-020-71707-2
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发表时间：
2020
影响因子：
4.6
通讯作者：
Tsujikawa Akitaka
中科院分区：
文献类型：
--
作者：
Otsuka Yuki;Oishi Akio;Miyata Manabu;Oishi Maho;Hasegawa Tomoko;Numa Shogo;Ikeda Hanako Ohashi;Tsujikawa Akitaka
遗传性视网膜营养不良（IRD）患者经常会出现恐惧症。然而，其机制尚未阐明。本研究的目的是探讨引起IRD患者畏光的主要波长，以及不同表型患者之间的差异。前瞻性招募了47名视网膜色素变性（RP）和22名锥-杆营养不良（CRD）患者。我们设计了两种有色玻璃：短波长滤光玻璃和中波长滤光玻璃。我们将视物恐惧症分为三种类型：（A）白色外，（B）明亮眩光，和（C）眼痛。患者被要求在戴眼镜和不戴眼镜的情况下为每种症状分配1分（完全不戴眼镜）和5分（完全适用）。在RP患者中，戴近视眼镜能更好地缓解畏光症状{“白色消失”（p < 0.01）和“眼痛”（p = 0.013）}。在CRD患者中，戴两种眼镜的改善无显著差异（p = 0.247-1.0）。所有首选MWF眼镜的RP患者都有牛眼黄斑病变。同时，只有15%的患者偏好戴近视眼镜（p < 0.001）。畏光症主要是由短波长的光在许多患者与IRD。然而，导致恐惧症的波长根据疾病而变化，并且可能根据病理状况而变化。
Inherited retinal dystrophy (IRD) patients often experience photophobia. However, its mechanism has not been elucidated. This study aimed to investigate the main wavelength of light causing photophobia in IRD and difference among patients with different phenotypes. Forty-seven retinitis pigmentosa (RP) and 22 cone-rod dystrophy (CRD) patients were prospectively recruited. We designed two tinted glasses: short wavelength filtering (SWF) glasses and middle wavelength filtering (MWF) glasses. We classified photophobia into three types: (A) white out, (B) bright glare, and (C) ocular pain. Patients were asked to assign scores between one (not at all) and five (totally applicable) for each symptom with and without glasses. In patients with RP, photophobia was better relieved with SWF glasses {“white out” (p < 0.01) and “ocular pain” (p = 0.013)}. In CRD patients, there was no significant difference in the improvement wearing two glasses (p = 0.247–1.0). All RP patients who preferred MWF glasses had Bull’s eye maculopathy. Meanwhile, only 15% of patients who preferred SWF glasses had the finding (p < 0.001). Photophobia is primarily caused by short wavelength light in many patients with IRD. However, the wavelength responsible for photophobia vary depending on the disease and probably vary according to the pathological condition.