Influence of drugs on vitamin D and calcium metabolism.
Influence of drugs on vitamin D and calcium metabolism.
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DOI：
10.4161/derm.20731
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发表时间：
2012-04-01
期刊：
影响因子：
--
通讯作者：
Kisters K
中科院分区：
文献类型：
--
作者：
Gröber U;Kisters K
在过去，药物和维生素D之间的相互作用在卫生保健实践中很少或根本没有受到关注。然而，由于越来越多的药物用于治疗患者，这个话题越来越相关。有几种药物会干扰维生素D和骨代谢。激活维生素D X受体的药物会破坏维生素D代谢和维生素D功能。除此之外，以药物为导向的维生素D补充可以改善一些药物的药理作用，如双膦酸盐，细胞抑制剂和他汀类药物。
In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins.