Points to consider when doing a trial primarily involving the heart
Points to consider when doing a trial primarily involving the heart
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DOI：
10.1093/rheumatology/kex198
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发表时间：
2017-09-01
期刊：
影响因子：
5.5
通讯作者：
Meune, Christophe
中科院分区：
文献类型：
--
作者：
Allanore, Yannick;Distler, Oliver;Meune, Christophe
心脏受累会加重 SSc 的严重程度，应对 SSc 患者进行仔细的调查和治疗。虽然它通常是亚临床的，但一旦出现症状，预后较差。几种补充工具（循环生物标志物、心电图、超声心动图、闪烁扫描或 MRI）可以评估所有不同的心脏结构（心内膜、心肌和心包）和心脏功能。治疗仍然是经验性的，但 SSc 的心脏试验可以为这种并发症的治疗添加数据。
Cardiac involvement contributes to the severity of SSc and should carefully be investigated and managed in SSc patients. Although it is commonly sub-clinical, once symptomatic it has a poor prognosis. Several complementary tools (circulating biomarkers, electrocardiography, echocardiography, scintigraphy or MRI) allow the assessment of all the various cardiac structures (endocardium, myocardium and pericardium) and heart function. Treatment remains empirical but cardiac trials in SSc can add data to the treatment of this complication.