Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities
Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities
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DOI：
10.1161/01.str.0000012808.81667.4b
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发表时间：
2002-04-01
期刊：
影响因子：
8.3
通讯作者：
Larsson, HBW
中科院分区：
文献类型：
--
作者：
Marstrand, JR;Garde, E;Larsson, HBW
背景和目的--越来越多的证据表明，白质高信号(WMH)在MR影像上不应被认为是良性的年龄相关性改变，而是具有临床后果的病理改变。先前比较WMH患者和正常对照组的研究已经报道了脑血流量和脑血管反应性的整体降低。在这项研究中，我们检测了局部血流动力学状态，以比较WMH和正常外观白质(NAWM)。方法-对21例正常85岁的受试者进行动态增强MRI检查，并联合应用乙酰唑胺。从具有不同信号权重的解剖图像的组合中，生成对应于灰质、白质和WMH的感兴趣区域。结果WMH组和NAWM组的脑血流量、脑血容量和平均通过时间均显著低于对照组(P=0.004)，平均通过时间明显延长(P<0.05)。
Background and Purpose-There is growing evidence that white matter hyperintensities (WMH) should not be considered as benign age-dependent changes on MR images but indicate pathological changes with clinical consequences. Previous studies comparing subjects with WMH to normal controls have reported global reductions in cerebral blood now (CBF) and cerebral vascular reactivity. In this study, we examined localized hemodynamic status to compare WMH to normal appearing white matter (NAWM).Methods-A group of 21 normal 85-year-old subjects were studied using dynamic contrast-enhanced MRI together with administration of acetazolamide. From a combination of anatomic images with different signal weighting, regions of interest were generated corresponding to gray and white matter and WMH. Localized measurements of CBF and cerebral blood volume (CBV) and mean transit time were obtained directly within WMH and NAWM.Results-When comparing WMH to NAWM, measurements showed significantly lower CBF (P=0.004) and longer mean transit time (P