Engineering of bypass conduits to improve patency
Engineering of bypass conduits to improve patency
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DOI：
10.1111/j.1365-2184.2004.00318.x
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发表时间：
2004-10
影响因子：
8.5
通讯作者：
S. Rashid;H. Salacinski;B. J. Fuller;G. Hamilton;A. Seifalian
中科院分区：
文献类型：
--
作者：
S. Rashid;H. Salacinski;B. J. Fuller;G. Hamilton;A. Seifalian
抽象。对于患有严重冠状动脉和远端外周血管疾病的患者，不适合血管成形术并且缺乏足够的自体血管，迫切需要改进当前的外科搭桥术选择。几十年来，旁路材料的任何真实的进展都没有达到主流外科实践。本次审查探讨了对这种情况可能采取的补救措施。考虑的选择是减少人工移植物血栓形成的方法，包括内皮细胞接种和新假体材料的开发。组织工程血管的前景是检查与具体看看肽如何可以提高细胞粘附到支架。
Abstract. For patients with severe coronary artery and distal peripheral vascular disease not amenable to angioplasty and lacking sufficient autologous vessels there is a pressing need for improvements to current surgical bypass options. It has been decades since any real progress in bypass material has reached mainstream surgical practice. This review looks at possible remedies to this situation. Options considered are methods to reduce prosthetic graft thrombogenicity, including endothelial cell seeding and developments of new prosthetic materials. The promise of tissue‐engineered blood vessels is examined with a specific look at how peptides can improve cell adhesion to scaffolds.