THE RELATIONSHIP BETWEEN THE CHEMICAL STRUCTURES AND MUTAGENIC SPECIFICITIES OF THE DNA LESIONS FORMED BY CHEMICAL AND PHYSICAL MUTAGENS
THE RELATIONSHIP BETWEEN THE CHEMICAL STRUCTURES AND MUTAGENIC SPECIFICITIES OF THE DNA LESIONS FORMED BY CHEMICAL AND PHYSICAL MUTAGENS
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DOI：
10.1016/0378-4274(93)90044-x
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发表时间：
1993-04-01
影响因子：
3.5
通讯作者：
WOOD, ML
中科院分区：
文献类型：
--
作者：
ESSIGMANN, JM;WOOD, ML
辐射，烷基化剂，和芳香胺和酰胺的诱变活性进行检查，从观察到的模式与premutagenic DNA病变的结构的诱变的角度来看。建立这种关系的一般方法涉及构建含有特定DNA加合物的病毒或质粒基因组。这种位点特异性修饰的基因组的体内复制导致突变的诱导，其特征在于DNA测序。人们发现，在这些简单的系统中出现的突变类型往往与有意或无意接触致癌物质的哺乳动物产生的肿瘤中发生的突变类型相匹配。
The mutagenic activities of radiation, alkylating agents, and aromatic amines and amides are examined from the perspective of relating the observed patterns of mutagenesis with the structures of the premutagenic DNA lesions. The general approach taken to establish such relationships has involved the construction of viral or plasmid genomes containing specific DNA adducts. The in vivo replication of such site-specifically modified genomes results in the induction of mutations, which are characterized by DNA sequencing. It is found that the mutation types that arise in these simple systems often match those occurring in tumors produced in mammals exposed intentionally or unintentionally to carcinogenic agents.