Molecular insights into human daily behavior
Molecular insights into human daily behavior
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DOI：
10.1073/pnas.0707772105
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发表时间：
2008-02-05
影响因子：
11.1
通讯作者：
Kramer, Achim
中科院分区：
文献类型：
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作者：
Brown, Steven A.;Kunz, Dieter;Kramer, Achim
人类在日常行为的时间上表现出很大的差异。我们和其他人以前曾提出，这种差异可能是由于内源性人体昼夜节律振荡器周期长度的改变而产生的。使用真皮成纤维细胞从皮肤活检的28名受试者的早期和晚期的chronotype（11“云雀”和17“猫头鹰”），我们研究了这两组的昼夜节律周期的长度，以及他们的能力相移和夹带环境和化学信号。我们不仅发现两类之间的周期长度的差异，但也有显着的变化的振幅和相移特性的昼夜节律振荡器之间的个人具有相同的“正常”的周期长度。数学模型表明，这些改变也可以解释这些受试者的极端行为表型。我们得出结论，人类。生物钟型不仅受昼夜节律振荡器周期长度的影响，而且受影响其振幅和相位的细胞成分的影响。在许多情况下，这些变化可以在原代真皮细胞的分子水平上进行研究。
Human beings exhibit wide variation in their timing of daily behavior. We and others have suggested, previously that such differences might arise because of alterations in the period length of the endogenous human circadian oscillator. Using dermal fibroblast cells from skin biopsies of 28 subjects of early and late chronotype (11 "larks" and 17 "owls"), we have studied the circadian period lengths of these two groups, as well as their ability to phase-shift and entrain to environmental and chemical signals. We find not only period length differences between the two classes, but also significant changes in the amplitude and phase-shifting properties of the circadian oscillator among individuals with identical "normal" period lengths. Mathematical modeling shows that these alterations could also account for the extreme behavioral phenotypes of these subjects. We conclude that human. chronotype may be influenced not only by the period length of the circadian oscillator, but also by cellular components that affect its amplitude and phase. In many instances, these changes can be studied at the molecular level in primary dermal cells.