An Evidence-Based Review of Quantitative SPECT Imaging and Potential Clinical Applications
An Evidence-Based Review of Quantitative SPECT Imaging and Potential Clinical Applications
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DOI：
10.2967/jnumed.112.111476
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发表时间：
2013-01-01
影响因子：
9.3
通讯作者：
Willowson, Kathy P.
中科院分区：
文献类型：
--
作者：
Bailey, Dale L.;Willowson, Kathy P.
SPECT传统上被认为是非定量的。然而，多模式伽马相机(SPECT/CT)、图像重建算法以及用于校正光子衰减和散射的复杂补偿技术的进步，现在使定量SPECT以类似于定量PET的方式成为可能(即，kBq.cm(-3)，标准化摄取值)。这篇综述考察了定量SPECT的证据，并展示了临床研究中重建的SPECT数据的准确性已在体内进行评估。使用基于CT的补偿校正的SPECT重建很容易将99m的准确度提高到体内放射性示踪剂已知浓度的+/-10%以内。还采用了其他放射性核素的量化方法。SPECT的光子探测效率(灵敏度)和空间分辨率仍然低于PET；然而，在某些情况下，它具有更长的放射性核素半衰期的好处，这可能更适合正在检查的生物过程，以及使用脉冲高度光谱来分离不同的放射性标记进行多示踪研究的能力。
SPECT has traditionally been regarded as nonquantitative. Advances in multimodality gamma-cameras (SPECT/CT), algorithms for image reconstruction, and sophisticated compensation techniques to correct for photon attenuation and scattering have, however, now made quantitative SPECT viable in a manner similar to quantitative PET (i.e., kBq.cm(-3), standardized uptake value). This review examines the evidence for quantitative SPECT and demonstrates clinical studies in which the accuracy of the reconstructed SPECT data has been assessed in vivo. SPECT reconstructions using CT-based compensation corrections readily achieve accuracy for Tc-99m to within +/- 10% of the known concentration of the radiotracer in vivo. Quantification with other radionuclides is also being introduced. SPECT continues to suffer from poorer photon detection efficiency (sensitivity) and spatial resolution than PET; however, it has the benefit in some situations of longer radionuclide half-lives, which may better suit the biologic process under examination, as well as the ability to perform multitracer studies using pulse height spectroscopy to separate different radiolabels.