Diffusion coefficient measurement using a temperature-controlled fluid for quality control in multicenter studies.
Diffusion coefficient measurement using a temperature-controlled fluid for quality control in multicenter studies.
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DOI：
10.1002/jmri.22363
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发表时间：
2011-10
影响因子：
4.4
通讯作者：
Ross, Brian D.
中科院分区：
文献类型：
--
作者：
Chenevert, Thomas L.;Galban, Craig J.;Ivancevic, Marko K.;Rohrer, Susan E.;Londy, Frank J.;Kwee, Thomas C.;Meyer, Charles R.;Johnson, Timothy D.;Rehemtulla, Alnawaz;Ross, Brian D.
介绍一种DW-MRI质量控制冰水体模的应用。DW-MRI已成为一种重要的肿瘤影像生物标志物，可用于诊断和早期治疗反应评估。通过多中心试验验证成像生物标记物需要跨地点的校准和性能测试。这个模子由一个中心管组成，里面装满了蒸馏水，周围环绕着冰水。在制备模体后，让大约30分钟达到热平衡。DW-MRI数据来自7个机构，来自3个供应商的20台MRI扫描仪和2个场强(1.5和3T)。在25天的时间里，在16天的不同时间里，该模型还在一个单一系统上进行了扫描。所有数据都被转移到密歇根大学的中央处理站点进行分析。结果表明，所有被测系统之间的测量ADC值的偏差为±5%，表明系统之间具有很好的一致性。单一系统在25天内的重复性也被发现在±5%的ADC值内。总体而言，在多中心试验中，使用冰水模体评估ADC被发现是一个合理的候选方案。这里描述的冰水体模是一种实用而通用的方法，可以随着MRI序列和硬件设计的不断变化来验证ADC测量的准确性，并且可以很容易地在多中心临床试验设计中实施。
To present the use of a quality control ice-water phantom for DW-MRI. DW-MRI has emerged as an important cancer imaging biomarker candidate for diagnosis and early treatment response assessment. Validating imaging biomarkers through multi-center trials requires calibration and performance testing across sites. The phantom consisted of a center tube filled with distilled water surrounded by ice-water. Following preparation of the phantom approximately 30 minutes was allowed to reach thermal equilibrium. DW-MRI data was collected at 7 institutions, 20 MRI scanners from three vendors and 2 field strengths (1.5 and 3T). The phantom was also scanned on a single system on 16 different days over a 25 day period. All data was transferred to a central processing site at the University of Michigan for analysis. Results revealed that the variation of measured ADC values between all systems tested was ±5% indicating excellent agreement between systems. Reproducibility of a single system over a 25 day period was also found to be within ±5% ADC values. Overall, the use of an ice water phantom for assessment of ADC was found to be a reasonable candidate for use in multi-center trials. The ice water phantom described here is a practical and universal approach to validate the accuracy of ADC measurements with ever changing MRI sequence and hardware design and can be readily implemented in multicenter clinical trial designs.
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影响因子：
2.2
作者：
Komlosh, M. E.;Horkay, F.;Basser, P. J.
通讯作者：
Basser, P. J.
影响因子：
5
作者：
Galban, Craig J.;Mukherji, Suresh K.;Ross, Brian D.
通讯作者：
Ross, Brian D.
影响因子：
3.3
作者：
Holz, M;Heil, SR;Sacco, A
通讯作者：
Sacco, A
影响因子：
2.9
作者：
Riches, S. F.;Hawtin, K.;de Souza, N. M.
通讯作者：
de Souza, N. M.
影响因子：
2.3
作者：
Chenevert, Thomas L.;Ross, Brian D.
通讯作者：
Ross, Brian D.