Altered diffusion in the frontal lobe in Parkinson disease
Altered diffusion in the frontal lobe in Parkinson disease
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DOI：
10.3174/ajnr.a0850
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发表时间：
2008-03-01
影响因子：
3.5
通讯作者：
Tuite, P.
中科院分区：
文献类型：
--
作者：
Kendi, A. T. Karagulle;Lehericy, S.;Tuite, P.
背景和目的：帕金森病(PD)是以基底节异常为特征的疾病。然而，帕金森病中有一些神经退行性改变延伸到基底节以外，标准磁共振成像不能充分评估这些改变。应用弥散张量成像(DTI)技术对13例对照组和12例非痴呆性帕金森病(PD)患者的脑灰质(GM)和脑白质(WM)进行对比研究。对DTI图像和解剖图像进行统计参数映射分析。患者接受了各种神经认知测量和统一帕金森病评定量表(UPDRS)停药(停药)和停药(正常服药)的评估。结果：PD参与者具有UPDRS停药和服药后的多巴反应特征，并且没有认知障碍。帕金森病患者双侧额叶，包括辅助运动区、辅助运动区和扣带回的分数各向异性(FA)降低。帕金森病患者的平均弥散系数和GM/WM衰减与对照组相比无显著差异。结论：DTI的统计参数图分析显示，额区FA的改变不会造成体积损失。这些结果证实，帕金森病患者的神经退行性变过程超出了基底节。
BACKGROUND AND PURPOSE: Parkinson disease (PD) is characterized by basal ganglia abnormalities. However, there are neurodegenerative changes in PD that extend beyond the basal ganglia and that are not sufficiently evaluated with standard MR imaging. The aim of this study was to characterize whole-brain gray matter (GM) and white matter (WM) changes in PID by using diffusion tensor imaging (DTI).MATERIALS AND METHODS: Thirteen control and 12 subjects with nondemented PD were examined by using DTI and 3D anatomic T1-weighted images. Statistical parametric mapping analyses of DTI and anatomic images were performed. Patients were evaluated with a variety of neurocognitive measures and the Unified Parkinson's Disease Rating Scale (UPDRS) OFF (cessation of medication) and ON (taking medications as normal) their antiparkinsonian medications.RESULTS: The PD participants had dopa-responsive features as ascertained by the UPDRS OFF versus ON medications and had no cognitive impairment. Decreased fractional anisotropy (FA) was observed in subjects with PD bilaterally in the frontal lobes, including the supplementary motor area, the presupplementary motor area, and the cingulum. There were no significant differences in mean diffusivity or GM/WM attenuation between PD subjects and controls.CONCLUSION: Statistical parametric mapping analysis of DTI showed changes in FA in frontal areas without volume loss. These results confirm that the neurodegenerative process extends beyond the basal ganglia in PD.