Treatment by hGH of Constitutional Delay of Growth and Adolescence
Treatment by hGH of Constitutional Delay of Growth and Adolescence
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hGH 治疗体质性生长迟缓和青春期
DOI：
10.1111/j.1651-2227.1986.tb10368.x
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
JR. Bierich
中科院分区：
文献类型：
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作者：
JR. Bierich
摘要。在体质性生长和青春期延迟（CDGA）中，所有生长和成熟参数均延迟2-4年。hGH分泌的激发试验给出正常值，但自发（内源性）分泌较低。这可以通过测量夜间hGH分泌来评估，此时正常受试者和CDGA患者之间的差异非常显著。除一名患者外，所有患者的hGH替代治疗均产生了生长突增，改善了他们的生长预后。一个新的系列的16 CDGA患者现在已经用hGH治疗了1-3年。第一年出现追赶式增长，第三年降至正常增长速度。这种正常的生长速度仍然比预处理速度快。虽然生长激素治疗可能是有效的CDGA，它可能只在案件与心理问题所产生的身材矮小。
ABSTRACT. In constitutional delay of growth and adolescence (CDGA), all growth and maturation parameters are delayed by 2–4 years. Provocation tests of hGH secretion give normal values, but spontaneous (endogenous) secretion is low. This can be assessed by measuring night‐time hGH secretion, when the differences between normal subjects and CDGA patients are highly significant. Replacement therapy with hGH produced growth spurts in all but one patient, improving their growth prognosis. A new series of 16 CDGA patients has now been treated with hGH for 1–3 years. Catch‐up growth was seen during the first year, which decreased to normal growth velocity by the third year. This normal growth rate is still faster than the pretreatment velocity. Although hGH therapy may be effective in CDGA, it may only be justified in cases with psychological problems arising from their short stature.