High-risk cervical epithelial neoplasia grade 1 treated by loop electrosurgical excision:: follow-up and value of HPV testing
High-risk cervical epithelial neoplasia grade 1 treated by loop electrosurgical excision:: follow-up and value of HPV testing
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DOI：
10.1016/j.ajog.2007.01.023
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发表时间：
2007-10-01
影响因子：
9.8
通讯作者：
Ordi, Jaume
中科院分区：
文献类型：
--
作者：
Alonso, Immaculada;Torne, Aureli;Ordi, Jaume
摘要目的:本研究旨在评估高危人乳头瘤病毒（HPV）检测在宫颈上皮内瘤变1级/低级别鳞状上皮内病变的随访中的价值，因为美国阴道镜和宫颈病理学会制定了风险标准（即阴道镜检查不满意或宫颈内膜刮除阳性）。宫颈上皮内瘤变（1级/低级别鳞状上皮内病变，或高危HPV感染超过2年，年龄超过40岁）。研究设计：77名宫颈上皮内瘤变1级/低级别鳞状上皮内病变的妇女，采用环形电切手术治疗，并随访阴道镜检查、细胞学检查和使用Hybrid Capture II进行高风险HPV检测。结果：标本中超过67%（67.6%）的女性宫颈上皮内瘤变为1级；22%为宫颈上皮内瘤变2- 3级；10.4%无病变。2- 3级宫颈上皮内瘤变100%阳性，1级宫颈上皮内瘤变93.5%阳性，无病变14.3%阳性(P
OBJECTIVE: This study was undertaken to evaluate the value of high- risk human papillomavirus ( HPV) testing in the follow- up of cervical intraepithelial neoplasia grade 1/ low- grade squamous intraepithelial lesion treated by loop electrosurgical excision procedure because of the risk criteria established by the American Society for Colposcopy and Cervical Pathology ( ie, unsatisfactory colposcopy or positive endocervical curettage, persistence of cervical intraepithelial neoplasia grade 1/ low- grade squamous intraepithelial lesion, or high- risk HPV infection for longer than 2 years and older than 40 years).STUDY DESIGN: Seventy- seven women with cervical intraepithelial neoplasia grade 1/ low- grade squamous intraepithelial lesion treated by loop electrosurgical excision procedure and followed- up with colposcopy, cytology, and high- risk HPV detection using Hybrid Capture II.RESULTS: More than 67% ( 67.6%) of women had cervical intraepithelial neoplasia grade 1 in the specimen; 22% a cervical intraepithelial neoplasia grade 2- 3; and 10.4% had no lesion. Pretreatment HPV testing was positive in 100% of cervical intraepithelial neoplasia grade 2- 3, in 93.5% of cervical intraepithelial neoplasia 1, and in 14.3% of cases with no lesion ( P