Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer
Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer
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DOI：
10.1016/j.ypmed.2005.12.014
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发表时间：
2006-03-01
影响因子：
5.1
通讯作者：
Alberg, AJ
中科院分区：
文献类型：
--
作者：
Gallicchio, L;Kouzis, A;Alberg, AJ
Objective.本研究的目的是采用前瞻性队列设计研究主动吸烟、家庭被动吸烟暴露和胰腺癌风险之间的关系。1963年（n = 45，749）和1975年（n = 48，172）在马里兰州的华盛顿县建立了两个队列。华盛顿县癌症登记处用于确定1963-1978年1963年队列和1975-1994年1975年队列中胰腺癌的发生率。采用Poisson回归分析主动吸烟和家庭被动吸烟与胰腺癌的关系。在两个队列中，目前主动吸烟与胰腺癌风险增加两倍相关。在每个队列的从不吸烟者中，暴露于家庭被动吸烟与胰腺癌风险增加无关，尽管由于病例数量较少，置信限较宽。这项研究进一步证明了目前活跃吸烟者患胰腺癌的风险大约增加一倍。我们的研究结果还表明，家庭被动吸烟暴露与胰腺癌风险无关，尽管我们的风险估计缺乏准确性。(c)2005年爱思唯尔公司All rights reserved.
Objective. The objective of this study was to examine the association between active cigarette smoking, household passive smoke exposure, and pancreatic cancer risk using a prospective cohort design.Methods. Two cohorts were established in Washington County, Maryland in 1963 (n = 45,749) and 1975 (n = 48,172). The Washington County Cancer Registry was used to ascertain the occurrence of pancreatic cancer in the 1963 cohort from 1963-1978 and in the 1975 cohort from 1975-1994. Poisson regression was used to analyze the associations between active smoking and household passive smoke exposure and pancreatic cancer risk.Results. Current active smoking was associated with a two-fold increased risk of pancreatic cancer in both cohorts. Among never-smokers in each cohort, exposure to household passive smoke was not associated with an increased risk of pancreatic cancer, although the confidence limits were wide due to a small number of cases.Conclusions. This study further documents the approximate doubling of pancreatic cancer risk in current active smokers. Our results also indicate that household passive smoke exposure is not associated with pancreatic cancer risk, although our risk estimates lacked precision. (c) 2005 Elsevier Inc. All rights reserved.