Cytomechanics of cadherin-mediated cell-cell adhesion
Cytomechanics of cadherin-mediated cell-cell adhesion
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DOI：
10.1016/s0955-0674(98)80031-8
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发表时间：
1998-10-01
影响因子：
7.5
通讯作者：
Nelson, WJ
中科院分区：
文献类型：
--
作者：
Adams, CL;Nelson, WJ
钙粘蛋白介导的粘附调节从最初的细胞-细胞识别到松散粘附的细胞簇，并最终到集落中的细胞的强烈压实组的转变。最近的研究已经描述了不同的作用，分子间聚集的钙粘蛋白，以及相互作用的钙粘蛋白与肌动蛋白细胞骨架在建立细胞-细胞粘附。整合钙粘蛋白介导的粘附的细胞力学作用将导致更好地了解钙粘蛋白如何调节组织形态发生。
Cadherin-mediated adhesion regulates transitions from initial cell-cell recognition to loosely adherent cell clusters and ultimately, to strongly compacted groups of cells in colonies. Recent studies have described distinct roles for intermolecular clustering of cadherins as well as interactions of cadherin with the actin cytoskeleton in establishing cell-cell adhesion. Integrating cytomechanical roles of cadherin-mediated adhesion will lead to a greater understanding of how cadherins regulate tissue morphogenesis.