Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency
Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency
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DOI：
10.1159/000452150
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发表时间：
2016-01-01
影响因子：
3.2
通讯作者：
Murad, Mohammad Hassan
中科院分区：
文献类型：
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作者：
Grimberg, Adda;DiVall, Sara A.;Murad, Mohammad Hassan
背景/目标：我们代表儿科内分泌学会的药物和治疗学以及伦理委员会，寻求更新 2003 年发布的有关生长激素 (GH) 使用的指南。由于特发性身材矮小 (ISS) 仍然是一个有争议的适应症，而且诊断挑战常常模糊 ISS、GH 缺乏症 (GHD) 和原发性 IGF-I 缺乏症 (PIGFD) 之间的区别，因此我们重点关注这三种诊断，从而首次将重组 IGF-I 疗法添加到 GH 指南中。方法：本指南是根据 GRADE 方法（建议分级、评估、制定和评估）制定的。结果：本指南利用现有最佳证据，为因 GHD、ISS 或 PIGFD 导致生长障碍的儿童和青少年的临床管理提供建议。结论：工作组建议将这些建议应用于临床实践，同时考虑不断发展的文献以及对每个患者的风险和益处。在许多情况下，仔细审查会突出需要进一步研究的领域。 (C) 2016 S. Karger AG，巴塞尔
Background/Aims: On behalf of the Drug and Therapeutics, and Ethics Committees of the Pediatric Endocrine Society, we sought to update the guidelines published in 2003 on the use of growth hormone (GH). Because idiopathic short stature (ISS) remains a controversial indication, and diagnostic challenges often blur the distinction between ISS, GH deficiency (GHD), and primary IGF-I deficiency (PIGFD), we focused on these three diagnoses, thereby adding recombinant IGF-I therapy to the GH guidelines for the first time. Methods: This guideline was developed following the GRADE approach (Grading of Recommendations, Assessment, Development, and Evaluation). Results: This guideline provides recommendations for the clinical management of children and adolescents with growth failure from GHD, ISS, or PIGFD using the best available evidence. Conclusion: The taskforce suggests that the recommendations be applied in clinical practice with consideration of the evolving literature and the risks and benefits to each individual patient. In many instances, careful review highlights areas that need further research. (C) 2016 S. Karger AG, Basel