Direct comparison of the neural substrates of recognition memory for words and faces
Direct comparison of the neural substrates of recognition memory for words and faces
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DOI：
10.1093/brain/122.6.1069
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发表时间：
1999-06-01
期刊：
影响因子：
14.5
通讯作者：
Hichwa, RD
中科院分区：
文献类型：
--
作者：
Kim, JJ;Andreasen, NC;Hichwa, RD
为了确定与单词和人脸识别记忆相关的相对特定的大脑区域以及两者共同的区域，我们使用[(H2O)-O-15]PET检测了健康志愿者与不同识别记忆认知任务相关的脑血流。任务包括在两种条件下（新奇和熟悉）识别两种类型的刺激（面孔和单词），以及两个基线任务（阅读单词和性别分类），用于识别特定区域的统计分析包括三种减法：新奇单词减去新奇面孔，熟悉单词减去熟悉面孔，阅读单词减去性别分类。这些分析揭示了用于识别单词和在一定熟悉程度下识别面孔的大脑回路的相对差异。为了找到面孔和单词识别的共同区域，在四个减法（新单词减去阅读单词，新面孔减去性别分类，熟悉的单词减去阅读单词，熟悉的面孔减去性别分类）中识别重叠区域。结果表明，单词识别的激活位点倾向于向左半球偏侧，分布在许多小的位点上，特别是在左侧颞中下回的后部，这些区域可能与书面单词识别过程中的词汇检索有关。相比之下，人脸识别的激活区域倾向于向右半球偏侧，并且位于一个大的聚集区域，包括右舌回和梭状回。这些发现表明，在单词和人脸识别记忆过程中，参与的神经通路截然不同，其中语义线索和知觉负荷分别在识别中起关键作用。对单词和人脸识别的共同区域的研究表明，前扣带和后扣带在识别记忆中具有可分离的功能，随着熟悉程度的变化而变化，小脑可能是所有四种类型的识别记忆过程的协调者。
For the purpose of identifying the relatively specific brain regions related to word and face recognition memory on the one hand and the regions common to both on the other, regional cerebral blood flow associated with different cognitive tasks for recognition memory was examined using [(H2O)-O-15]PET in healthy volunteers. The tasks consisted of recognizing two types of stimuli (faces and words) in two conditions (novel and familiar), and two baseline tasks (reading words and gender classification), The statistical analyses used to identify the specific regions consisted of three subtractions: novel words minus novel faces, familiar words minus familiar faces, and reading words minus gender classification. These analyses revealed relative differences in the brain circuitry used for recognizing words and for recognizing faces within a defined level of familiarity, In order to find the regions common to both face and word recognition, overlapping areas in four subtractions (novel words minus reading words, novel faces minus gender classification, familiar words minus reading words, and familiar faces minus gender classification) were identified, The results showed that the activation sites in word recognition tended to be lateralized to the left hemisphere and distributed as numerous small loci, and particularly included the posterior portion of the left middle and inferior temporal gyri, These regions may be related to lexical retrieval during written word recognition. In contrast, the activated regions for face recognition tended to be lateralized to the right hemisphere and located in a large aggregated area, including the right lingual and fusiform gyri, These findings suggest that strikingly different neural pathways are engaged during recognition memory for words and for faces, in which a critical role in discrimination is played by semantic cueing and perceptual loading, respectively, In addition, the investigation of the regions common to word and face recognition indicates that the anterior and posterior cingulate have dissociable functions in recognition memory that vary with familiarity, and that the cerebellum may serve as the co-ordinator of all four types of recognition memory processes.