Salacia chinensis Stem Extract and Its Thiosugar Sulfonium Constituent, Neokotalanol, Improves HbA1c Levels in ob/ob Mice
Salacia chinensis Stem Extract and Its Thiosugar Sulfonium Constituent, Neokotalanol, Improves HbA1c Levels in ob/ob Mice
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五层龙茎提取物及其硫糖锍成分 Neokotalanol 可提高 ob/ob 小鼠的 HbA1c 水平
DOI：
10.1007/s11418-019-01311-w
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发表时间：
2019
影响因子：
3.3
通讯作者：
Morikawa Toshio
中科院分区：
文献类型：
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作者：
Kobayashi Masakazu;Akaki Junji;Yamaguchi Yasuyo;Yamasaki Hiroo;Ninomiya Kiyofumi;Pongpiriyadacha Yutana;Yoshikawa Masayuki;Muraoka Osamu;Morikawa Toshio
用遗传性肥胖高血糖小鼠（inob/obmice）评价了五层龙茎热水提取物（SCE）的抗糖尿病作用。给toob/ob小鼠喂饲含0.20和0.50%SCE的饲料23天，可显著抑制血糖和HbA 1c水平的升高，而体重和摄食量无显著变化。为了表征具有强效α-葡萄糖苷酶抑制活性的硫代糖锍成分新可可他醇（1）的抗糖尿病作用，我们进行了类似的体内研究。在给予含0.0003%新可可他烷醇（1）的饲料20天后，inob/ob小鼠的HbA 1c水平显著降低。这些结果表明，SCE和新可可他醇（1）是开发新型抗糖尿病药物的潜在先导。
The antidiabetic effects of a hot water extract of the stems ofSalacia chinensis(SCE) were evaluated in vivo inob/obmice (genetically obese hyperglycemic mice). Administration of dietary feed containing 0.20 and 0.50% of SCE for 23 days toob/obmice significantly suppressed the elevation of both blood glucose and HbA1c levels, without significantly changing body weight and food intake. To characterize the antidiabetic effects of the thiosugar sulfonium constituent neokotalanol (1), which has potentα-glucosidase inhibitory activity, we performed a similar in vivo study. HbA1c levels were significantly suppressed inob/obmice after the administration of dietary feed containing 0.0003% of neokotalanol (1) for 20 days. These results indicate that SCE and neokotalanol (1) are potential leads for the development of novel antidiabetic agents.