Visual analogue scale scoring and ranking: A suitable and sensitive method for assessing scar quality?
Visual analogue scale scoring and ranking: A suitable and sensitive method for assessing scar quality?
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DOI：
10.1097/01.prs.0000232378.88776.b0
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发表时间：
2006-09-15
影响因子：
3.6
通讯作者：
Ferguson, Mark W. J.
中科院分区：
文献类型：
--
作者：
Duncan, Jonathan A. L.;Bond, Jeremy S.;Ferguson, Mark W. J.
背景：疤痕评估领域缺乏标准的方法。以前的方法都集中在广泛的疤痕类型，导致较差的敏感性和减少其歧视effictiveness.Methods：作为一项临床试验的一部分，调查的疤痕改善疗效的转化生长因子-β 3，作者研究了使用的视觉模拟量表和疤痕排名作为疤痕评估工具。瘢痕摄影图像进行了评估，使用一个新开发的计算机瘢痕评估系统的外部laypanel.Results：共收集了4296瘢痕图像的视觉模拟量表评估和2148瘢痕对收集瘢痕排名。排名数据的内部一致性为100%，视觉模拟量表一致性数据的差异非常接近于零。减少外部面板中评估者的数量显著提高了组内相关系数。从第1个月到第12个月，视觉模拟量表评分差异的相关系数表明，评估者可靠地注意到成熟瘢痕的变化。结合逻辑回归与0.72的曲线下面积在受试者工作特征曲线分析，视觉模拟量表评分被证明是一个高度统计学显着的预测一个良好的scars.Conclusions：作者已经表明视觉模拟量表疤痕评分和疤痕排名方法是一致的，可靠的，有效的，可行的。这些用于瘢痕评估的方法是高度敏感的，并且能够可靠地测量瘢痕质量的差异，使它们成为有价值的技术，达到未满足的临床需求，并且能够调查瘢痕质量的变化（例如，随着时间或在治疗干预之后）。
Background: The field of scar assessment lacks a standard methodology. Previous methods have focused on a wide range of scar types, resulting in poorer sensitivity and diminishing their discriminatory effectiveness.Methods: As part of a clinical trial investigating the scar-improving efficacy of transforming growth factor-beta 3, the authors investigated the use of a visual analogue scale and scar ranking as scar assessment tools. Scar photographic images were assessed using a newly developed computerized scar assessment system by an external lay panel.Results: A total of 4296 scar images were collected for visual analogue scale assessment and 2148 scar pairs were collected for scar ranking. Intrarater consistency was 100 percent for the ranking data, with differences very close to zero for the visual analogue scale consistency data. Reducing the number of assessors in the external panel significantly improved intraclass correlation coefficients. From month 1 to month 12, the correlation coefficients for the difference in visual analogue scale score showed that the assessors reliably noted the changes in the maturing scars. Combining logistic regression with an area under the curve of 0.72 in a receiver operating characteristic curve analysis, the visual analogue scale score was shown to be a highly statistically significant predictor of a good scar.Conclusions: The authors have shown the visual analogue scale scar scoring and scar ranking methods to be consistent, reliable, valid, and feasible. These methods for scar assessment are highly sensitive and capable of reliably measuring differences in scar quality, making them valuable techniques, reaching an unmet clinical need, and enabling investigation of changes in scar quality (e.g., with time or after therapeutic intervention).