Laser light triggered-activated carbon nanosystem for cancer therapy
Laser light triggered-activated carbon nanosystem for cancer therapy
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用于癌症治疗的激光触发活性碳纳米系统
DOI：
10.1016/j.biomaterials.2012.11.027
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发表时间：
2013-02-01
期刊：
影响因子：
14
通讯作者：
Wu, Qiang
中科院分区：
文献类型：
--
作者：
Chu, Maoquan;Peng, Jinliang;Wu, Qiang
在碳基纳米材料中，活性炭（AC）可能是肿瘤治疗药物的理想载体。在这里，我们发现了一个新的性质的纳米活性炭（NAC）具有窄的尺寸分布，即快速转换光的热能在体外和体内。用655-nm激光照射20分钟后，200 μ L NAC（1 mg/mL）的水悬浮液显示出超过35 ℃的快速温度升高;这在有效肿瘤治疗的温度范围内。我们证明了竹纳米AC（BNAC）孵育的肺癌细胞（H-1299）在激光照射后被高效杀死。此外，尺寸小于已注射BNAC的激光点的小鼠肿瘤在照射后消失。对于大于激光光斑面积的肿瘤，光敏剂ZnPc的掺入明显增加了BNAC的肿瘤生长抑制效率。当光热和光动力疗法组合施用时，发现BNAC-ZnPc表现出协同效应。这些结果表明NAC可用于高效癌症光疗。(C)2012爱思唯尔有限公司保留所有权利。
Among carbon-based nanomaterials, activated carbon (AC) may be an ideal candidate as a carrier for tumor therapeutic agents. Here we found a new property of nanoscale activated carbon (NAC) with narrow size distribution, namely the rapid conversion of light to thermal energy both in vitro and in vivo. An aqueous suspension of 200 mu L of NAC (1 mg/mL) exhibited a rapid temperature increase of more than 35 C after irradiation for 20 min with a 655-nm laser; this was within the temperature range for effective tumor treatment. We demonstrated that lung cancer cells (H-1299) incubated with bamboo nano-AC (BNAC) were killed with high efficiency after laser irradiation. In addition, mouse tumors with sizes smaller than the laser spot that had been injected with BNAC disappeared after irradiation. For tumors larger than the laser spot area, the incorporation of the photosensitizer ZnPc obviously increased the tumor growth inhibition efficiency of BNAC. BNAC-ZnPc was found to exhibit a synergistic effect when photothermal and photodynamic therapies were administered in combination. These results indicated that NAC can be used for high efficiency cancer phototherapy. (C) 2012 Elsevier Ltd. All rights reserved.