EXPRESSION OF THE NUCLEAR ONCOGENE P53 IN COLON TUMORS
EXPRESSION OF THE NUCLEAR ONCOGENE P53 IN COLON TUMORS
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DOI：
10.1002/path.1711570304
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发表时间：
1989-03-01
影响因子：
7.3
通讯作者：
WALBOOMERS, JMM
中科院分区：
文献类型：
--
作者：
VANDENBERG, FM;TIGGES, AJ;WALBOOMERS, JMM
核肿瘤抗原p53由位于人17号染色体p臂上的基因表达，这是结肠癌中经常缺失的区域。应用抗p53单克隆抗体，对结肠癌和异型增生管状腺瘤进行免疫组化分析，以研究p53表达与异型增生或恶性之间的关系。用这种方法在55%的结肠癌（n = 29）中检测到p53，在8%的腺瘤（n = 74）中，在异型增生的上皮细胞中发现灶性核p53表达。一般来说，息肉的这些p53阳性区域在组织学上与邻近的小管无法区分。有时，在高度发育不良上皮的病灶中发现p53阳性细胞核。结果提示，p53基因的表达可能是异型增生结肠息肉恶变过程的一部分。
The nuclear tumour antigen p53 is expressed by a gene localized on the p‐arm of human chromosome 17, a region frequently deleted in colon carcinomas. Using a monoclonal antibody to p53 antigen, immunohistochemical analysis of carcinomas and dysplastic tubular adenomas of the colon has been performed to study the relation between p53 expression and dysplasia or malignancy. With this methods p53 was detectable in 55 per cent of colon carcinomas (n = 29).In 8 per cent of adenomas (n = 74), focal nuclear p53 expression was found in dysplastic epithelial cells. In general, these p53‐positive regions of the polyps were histologically indistinguishable from the neighbouring tubuli. Sometimes the p53‐positive nuclei were found in a focus of more highly dysplastic epithelium. The results suggest that expression of the p53 gene may be part of the process of malignant transformation of dysplastic colon polyps.