Clinical and social correlates of duration of untreated psychosis among adult-onset psychosis in Hong Kong Chinese: the JCEP study
Clinical and social correlates of duration of untreated psychosis among adult-onset psychosis in Hong Kong Chinese: the JCEP study
复制标题
DOI：
10.1111/eip.12094
复制
发表时间：
2015-04-01
影响因子：
2
通讯作者：
Chen, Eric Yu-Hai
中科院分区：
文献类型：
--
作者：
Hui, Christy Lai-Ming;Lau, Winnie Wing-Yin;Chen, Eric Yu-Hai
目的了解导致治疗延迟的因素，为精神障碍的早期发现和干预策略提供信息。然而，现有的数据是混合的，主要在早发性年轻患者中进行。我们研究了未经治疗的精神病（DUP）的持续时间和它的临床和社会人口学相关性在一个大的队列的成人发病patients with psychiatris.MethodsA共360例首次发病的精神病患者年龄在26-55岁连续招募作为一个对照研究的一部分，在香港中国的早期精神病干预服务。人口统计学，社会人口学和临床特征有关的DUP进行了评估4个月内onset.ResultsThe人口的平均发病年龄为36.6岁（SD=8.7）。平均和中位DUP分别为515天（SD=1091）和93天（四分位数范围为20 - 382.3）。多因素回归分析显示，起病隐匿、住院治疗、精神分裂症诊断、自知力差、发病年龄小均延长DUP。DUP是不相关的病前功能，家庭参与在寻求帮助和living alone.ConclusionsThe初始期未经治疗的精神病是由多种因素决定的。家庭参与是否被认为是缩短或延长DUP的一种社会支持需要进一步研究。地方精神病早期干预计划在制定个性化计划时应参考这些研究结果，以减少延误。
AimUnderstanding factors that contribute to treatment delay would inform early detection and intervention strategies in psychotic disorders. However, existing data were mixed and primarily conducted among early-onset young patients. We examined duration of untreated psychosis (DUP) and its clinical and sociodemographic correlates in a large cohort of adult-onset patients with psychosis.MethodsA total of 360 patients with first-onset psychosis aged 26-55 years were recruited consecutively as part of a controlled study of an early psychosis intervention service in Hong Kong Chinese. Demographic, sociodemographic and clinical characteristics relating to DUP were assessed within 4 months of onset.ResultsThe population had a mean onset age of 36.6 years (SD=8.7). The mean and median DUP were 515 days (SD=1091) and 93 days (inter-quartile range from 20 to 382.3), respectively. Multivariate regression analysis suggested that insidious mode of onset, hospitalization, a diagnosis of schizophrenia, poorer insight and younger age at onset significantly prolonged DUP. DUP was not related to premorbid functioning, family involvement during help seeking and living alone.ConclusionsThe initial period of untreated psychosis is determined by multiple factors. Whether family involvement is considered a kind of social support in shortening or prolonging DUP needs further examination. Local early intervention program for psychosis should take reference from these findings when formulating personalized plans to reduce delay.