Cholinergic Signaling Dynamics and Cognitive Control of Attention.
Cholinergic Signaling Dynamics and Cognitive Control of Attention.
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胆碱能信号动力学和注意力的认知控制。
DOI：
10.1007/7854_2020_133
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发表时间：
2020
影响因子：
--
通讯作者：
Bangasser,DebraA
中科院分区：
文献类型：
--
作者：
Parikh,Vinay;Bangasser,DebraA
中枢胆碱能系统是参与多种行为过程的重要神经递质系统之一。基底前脑皮质胆碱能输入系统的激活是皮质信息处理的关键步骤。本章探讨了最近的发展，说明皮层胆碱能传递介导定义的认知操作，这是相反的传统观点，乙酰胆碱作为一个缓慢作用的神经调质，影响唤醒皮层范围。具体来说，我们审查的证据表明，相胆碱能信号在前额叶皮层是一个因果介质的信号检测。此外，研究支持胆碱能输入在自上而下的注意控制中的神经调节作用进行了总结。最后，我们回顾新的发现，揭示性别差异和激素调节胆碱能注意系统。
The central cholinergic system is one of the most important modulator neurotransmitter system implicated in diverse behavioral processes. Activation of the basal forebrain cortical cholinergic input system represents a critical step in cortical information processing. This chapter explores recent developments illustrating cortical cholinergic transmission mediate defined cognitive operations, which is contrary to the traditional view that acetylcholine acts as a slowly acting neuromodulator that influences arousal cortex-wide. Specifically, we review the evidence that phasic cholinergic signaling in the prefrontal cortex is a causal mediator of signal detection. In addition, studies that support the neuromodulatory role of cholinergic inputs in top-down attentional control are summarized. Finally, we review new findings that reveal sex differences and hormonal regulation of the cholinergic-attention system.