Localisation of epileptic foci with electric, magnetic and combined electromagnetic models
Localisation of epileptic foci with electric, magnetic and combined electromagnetic models
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DOI：
10.1016/s0013-4694(97)00142-9
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发表时间：
1998-04-01
期刊：
影响因子：
--
通讯作者：
Wollinsky, KH
中科院分区：
文献类型：
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作者：
Diekmann, V;Becker, W;Wollinsky, KH
我们比较了(1)EEG，(2)脑磁图(MEG)和(3)联合EEG/MEG数据在一组耐药局灶性癫痫患者中癫痫灶的定位。在4壳球形头部近似下，通过移动偶极子模型来定位单个癫痫事件。通过计算所有局部事件的空间密度分布(DD)来总结患者的癫痫活动，DD的重心被认为是最可能的癫痫发作产生地点。为了验证这些位点，我们选择了6名患者，其中癫痫发作可能与MRI上清晰可识别的病变有关。平均而言，EEG/MEG联合方法的误差最小(计算的轨迹到最近的病变边缘的距离为1.8 cm)，单独使用MEG的误差最大(2.4 cm)，而EEG的误差最大(2.2 cm)。在个别患者中，EEG/MEG也会处于中等水平，但绝不是最差的。总而言之，与仅使用EEG或仅使用MEG相比，结合EEG/MEG似乎是一种更可靠的本地化方法。最后，我们还报告了在脑电/脑磁图记录过程中，使用巴比妥酸甲己胺作为一种安全的方法来增加棘波事件的数量。(C)1998年爱思唯尔爱尔兰科学有限公司。
We compare the localisation of epileptic foci by means of (1) EEG, (2) magnetoencephalography (MEG) and (3) combined EEG/MEG data in a group of patients suffering from pharmaco-resistant focal epilepsy. Individual epileptic events were localised by means of a moving dipole model in a 4-shell spherical head approximation. A patient's epileptic activity was summarised by calculating the spatial density distribution (DD) of all localised events, and the centre of gravity of DD was considered the most likely locus of seizure generation. To verify these loci a subgroup of 6 patients was selected, in which seizures could be related to a clearly identifiable lesion in MRI. On average, the combined EEG/MEG approach resulted in the smallest error (1.8 cm distance between calculated locus and the nearest lesion border); using only MEG yielded the largest error (2.4 cm), while EEG resulted in an intermediate value (2.2 cm). In the individual patients, EEG/MEG would also rank intermediate, but never worst. In summary, combining EEG/MEG appears to be a more robust approach to localisation than using only EEG or only MEG. Finally, we also report on the use of the barbiturate methohexital as a safe method of increasing the number of spike events during an EEG/MEG recording session. (C) 1998 Elsevier Science Ireland Ltd.