Laser speckle imaging allows real-time intraoperative blood flow assessment during neurosurgical procedures
Laser speckle imaging allows real-time intraoperative blood flow assessment during neurosurgical procedures
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DOI：
10.1038/jcbfm.2013.42
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发表时间：
2013-07-01
影响因子：
6.3
通讯作者：
Vajkoczy, Peter
中科院分区：
文献类型：
--
作者：
Hecht, Nils;Woitzik, Johannes;Vajkoczy, Peter
目前，还没有足够的技术用于术中监测脑血流量（CBF）。为评价激光散斑成像（LSI）评估相对CBF，对30例接受直接手术血运重建治疗动脉性脑血管病（ACVD）、烟雾病（MMD）或巨大动脉瘤的患者和8例因血流动力学损害以外的原因接受颅内手术的对照患者进行了LSI。通过基线灌注和CO2反应性测试研究LSI的适用性和灵敏度。在旁路试验阻塞和流动启动程序期间评估LSI的动力学。激光散斑成像允许对相对微循环流量进行稳健（伪）定量评估，标准旁路移植术导致ACVD和MMD患者术后基线灌注值显著升高。与对照组（31.2+/-5%; P < 0.01）相比，ACVD（9.6+/-9%）和MMD（8.5+/-8%）患者的CO2反应性显著降低，这表明LSI的适用性和敏感性。
Currently, there is no adequate technique for intraoperative monitoring of cerebral blood flow (CBF). To evaluate laser speckle imaging (LSI) for assessment of relative CBF, LSI was performed in 30 patients who underwent direct surgical revascularization for treatment of arteriosclerotic cerebrovascular disease (ACVD), Moyamoya disease (MMD), or giant aneurysms, and in 8 control patients who underwent intracranial surgery for reasons other than hemodynamic compromise. The applicability and sensitivity of LSI was investigated through baseline perfusion and CO2 reactivity testing. The dynamics of LSI were assessed during bypass test occlusion and flow initiation procedures. Laser speckle imaging permitted robust (pseudo-) quantitative assessment of relative microcirculatory flow and standard bypass grafting resulted in significantly higher postoperative baseline perfusion values in ACVD and MMD. The applicability and sensitivity of LSI was shown by a significantly reduced CO2 reactivity in ACVD (9.6+/-9%) and MMD (8.5+/-8%) compared with control (31.2+/-5%; P