ANTIBACTERIAL ACTIVITY OF MUPIROCIN (PSEUDOMONIC ACID), A NEW ANTIBIOTIC FOR TOPICAL USE
ANTIBACTERIAL ACTIVITY OF MUPIROCIN (PSEUDOMONIC ACID), A NEW ANTIBIOTIC FOR TOPICAL USE
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DOI：
10.1128/aac.27.4.495
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发表时间：
1985-01-01
影响因子：
4.9
通讯作者：
WHITE, AR
中科院分区：
文献类型：
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作者：
SUTHERLAND, R;BOON, RJ;WHITE, AR
莫匹罗星（假单胞酸 A）是一种由荧光假单胞菌产生的抗生素，对葡萄球菌和链球菌以及某些革兰氏阴性菌（包括流感嗜血杆菌和淋病奈瑟菌）表现出高水平的活性，但对大多数革兰氏阴性杆菌和厌氧菌的活性要低得多。几乎所有金黄色葡萄球菌和表皮葡萄球菌的临床分离株，包括多重耐药菌株，都是敏感的。莫匹罗星与临床可用抗生素之间不存在交叉耐药性，体外耐药变异体的选择发生频率较低。莫匹罗星与人血清蛋白高度结合（95% 结合），在人血清存在下活性降低 10 至 20 倍。莫匹罗星的活性不受接种量的影响很大，但在酸性培养基中显着增强。在杀菌活性测试中，最低杀菌浓度比最低抑菌浓度高8至32倍，并且抗生素在时间杀灭测试中表现出缓慢的杀菌作用，在37℃下24小时后杀菌率为90-99%。 C.
Mupirocin (pseudomonic acid A), an antibiotic produced by Pseudomonas fluorescens, showed a high level of activity against staphylococci and streptococci, and against certain gram-negative bacteria including Haemophilus influenzae and Neisseria gonorrhoeae, but was much less active against most gram-negative bacilli and anaerobes. Nearly all clinical isolates of Staphylococcus aureus and S. epidermidis, including multiply resistant strains, were susceptible. There was no cross-resistance between mupirocin and clinically available antibiotics, and the selection of resistant variants in vitro occurred at a low frequency. Mupirocin was highly bound (95% bound) to the protein of human serum and activity was reduced 10- to 20-fold in the presence of human serum. The activity of mupirocin was not greatly influenced by inoculum size but was significantly enhanced in acid medium. In tests of bactericidal activity, minimal bactericidal concentrations were 8- to 32-fold higher than minimal inhibitory concentrations and the antibiotic demonstrated a slow bactericidal action in time-kill tests, resulting in 90-99% killing after 24 h at 37.degree. C.